Klinik und Poliklinik für Neurologie

Publikationen 2017

Altmann J*, Büchner B*, Nadaj-Pakleza A, Schäfer J, Jackson S, Lehmann D, Deschauer M, Kopajtich R, Lautenschläger R, Kuhn KA, Karle K, Schöls L, Schulz JB, Weis J, Prokisch H, Kornblum C*, Claeys KG*, Klopstock T*. Expanded phenotypic spectrum of the m.8344A>G "MERRF" mutation: data from the German mitoNET registry. J Neurol. 2016 May;263(5):961-72. doi: 10.1007/s00415-016-8086-3. PubMed PMID: 26995359. *authors contributed equally

Bloem BR, Rascol O, Meissner WG, Hardy JA, Revesz T, Holton JL, Gasser T, Wenning GK, Singleton AB, Houlden H; European Multiple System Atrophy Study Group and the UK Multiple System Atrophy Study Group. . A genome-wide association study in multiple system atrophy. Neurology. 2016 Oct 11;87(15):1591-1598. PubMed PMID: 27629089; PubMed Central PMCID: PMC5067544.

Cihoric N, Tsikkinis A, Minniti G, Lagerwaard FJ, Herrlinger U, Mathier E, Soldatovic I, Jeremic B, Ghadjar P, Elicin O, Lössl K, Aebersold DM, Belka C, Herrmann E, Niyazi M. Current status and perspectives of interventional clinical trials for glioblastoma - analysis of ClinicalTrials.gov. Radiat Oncol. 2017 Jan 3;12(1):1. doi: 10.1186/s13014-016-0740-5. Review. PMID: 28049492

Geisler T, Poli S, Meisner C, Schreieck J, Zuern CS, Nägele T, Brachmann J, Jung W, Gahn G, Schmid E, Bäezner H, Keller T, Petzold GC, Schrickel JW, Liman J, Wachter R, Schön F, Schabet M, Lindner A, Ludolph AC, Kimmig H, Jander S, Schlegel U, Gawaz M, Ziemann U. Apixaban for treatment of embolic stroke of undetermined source (ATTICUS randomized trial): Rationale and study design. Int J Stroke. 2016 Nov 23. pii: 1747493016681019. [Epub ahead of print] PubMed PMID: 27881833.

Giovannoni G, Cohen JA, Coles AJ, Hartung HP, Havrdova E, Selmaj KW, Margolin DH, Lake SL, Kaup SM, Panzara MA, Compston DA; Arnold D, Cohen JA, Coles A, Compston A, Confavreux C, Fox E, Hartung HP, Havrdova E, Selmaj K, Weiner H, Panitch H, Clifford D, Antel J, Barkhof F, Snydman D, DeGroot L, Cines D, D'Agostino R, Greenberg B, Krauss J, Limmroth V, Markowitz C, Naismith R, Tabby D, Deri NH, Boundy K, Broadley S, Dreyer MD, Hodgkinson S, King JO, Macdonell R, Racp F, McCombe PA, Paine MA, Reddel S, Schwartz R, Vucic S, Karl Vass MD, Dominique Dive P, Dubois BD, Sindic C, Callegaro D, Ferreira ML, Barreto Martins MM, Tilbery C, Charles Ayotte, Brunet DG, Freedman MS, Grand'Maison F, Jacques FH, Kremenchutzky M, Traboulsee AL, Licia Antonelli MD, Brinar V, Habek M, Piskać SK, Trkanjec Z, Vladić A, Ivana Kovarova, Rektor I, Talab R, Vachova M, Petersen T, Ravnborg M, Sørensen PS, Michel Clanet, Clavelou P, de Seze J, Debouverie M, Edan G, Lubetzki C, Moreau T, Vermersch P, Baum K, Haas J, Hemmer B, Herrlinger U, Köhler W, Ochs G, Stangel M, Tumani H, Urban PP, Zettl UK, Ziemssen T, Anat Achiron, Karni A, Dembinsky AV, Bertolotto A, Capra R, Comi G, Durelli L, Ghezzi A, Mancardi GL, Marrosu MG, Pozzilli C, Caballero NS, Mendoza CV, Violante Villanueva JA, Raymond M M Hupperts, van Munster E, Wojciech Kozubski, Selmaj K, Stelmasiak Z, Barantsevich ER, DMedSc, Belova AN, Boyko AN, Gusev EI, Malkova NA, Perfiliev SV, Poverennova IE, Skoromets AA, Stolyarov ID, Yakupov EZ, Zavalishin IA, Dinčić E, Drulović J, Nadj Č, Tončev G, González RA, Ayuso GI, Fernández Ó, Montalbán X, Jan Lycke, Svenningsson A, Kobys TO, Nehrych TI, Voloshyna NP, Giovannoni G, Rog DJ, Scolding NJ, Sharrack B, Abou Zeid NE, Agius MA, Doan-Do Bass A, Bigley GK Jr, Bomprezzi R, Boster A, Boutwell CM, Braley TJ, Cascione MC, Clauser G, Cooper JA, Crayton HJ, Dunn J, Edwards KR, Elias S, Evans BK, Fletcher MH, Ford CC, Frohman EM, Gazda SK, Giancarlo T, Gitt JS, Glyman SA, Goodman A, Gottschalk C, Gottesman MH, Grazioli EM, Gudesblatt M, Gupta AS, Herbert J, Honeycutt WD, Hughes BL, Hunter SF, Janus TJ, Javed A, Jones DE, Jubelt B, Henson LJ, Khan OA, Kita M, Kirzinger S, Krieger S, Krolczyk SJ, LaGanke CC, Lallana EC, Lathi ES, Lava NS, Lynch SG, Machanic BI, Markovic-Plese S, Mattson DH, Mikol DD, Miller A, Miller TA, Minagar A, Mitchell GW, Moses H Jr, Negroski D, Pardo G, Picone MA, Preiningerova J, Rammohan KW, Riley CS, Riskind PN, Rizvi SA, Rossen M, Rothstein TL, Rowe VD 3rd, Royal W 3rd, Schaeffer JD, Sheppard CA, Shubin RA, Silliman SL, Singer BA, Stein LS, Steingo B, Sullivan HC, Thoits TK, Thrower BW, Twyman CL, Vaishnav AG, Vincent SG, Vollmer T, Waldman SR, Weiner LP, Wendt JK, Wingerchuk DM, Wray SE, Wynn DR. Alemtuzumab improves preexisting disability in active relapsing-remitting MS patients. Alemtuzumab improves preexisting disability in active relapsing-remitting MS patients. Neurology. 2016 Nov 8;87(19):1985-1992. PMID: 27733571

Hallmann K, Kudin AP, Zsurka G, Kornblum C, Reimann J, Stüve B, Waltz S, Hattingen E, Thiele H, Nürnberg P, Rüb C, Voos W, Kopatz J, Neumann H, Kunz WS. Loss of the smallest subunit of cytochrome c oxidase, COX8A, causes Leigh-like syndrome and epilepsy. Brain. 2016 Feb;139 (Pt 2):338-45. doi: 10.1093/brain/awv357. PubMed PMID: 26685157.

Hattingen E, Beyle A, Müller A, Klockgether T, Kornblum C. Wernicke encephalopathy: SWI detects petechial hemorrhages in mammillary bodies in vivo. Neurology. 2016 Nov 1;87(18):1956-1957. PubMed PMID: 27799475.

Herrlinger U, Schäfer N, Steinbach JP, Weyerbrock A, Hau P, Goldbrunner R, Friedrich F, Rohde V, Ringel F, Schlegel U, Sabel M, Ronellenfitsch MW, Uhl M, Maciaczyk J, Grau S, Schnell O, Hänel M, Krex D, Vajkoczy P, Gerlach R, Kortmann RD, Mehdorn M, Tüttenberg J, Mayer-Steinacker R, Fietkau R, Brehmer S, Mack F, Stuplich M, Kebir S, Kohnen R, Dunkl E, Leutgeb B, Proescholdt M, Pietsch T, Urbach H, Belka C, Stummer W, Glas M. Bevacizumab Plus Irinotecan Versus Temozolomide in Newly Diagnosed O6-Methylguanine-DNA Methyltransferase Nonmethylated Glioblastoma: The Randomized GLARIUS Trial. J Clin Oncol. 2016 May 10;34(14):1611-9. doi: 10.1200/JCO.2015.63.4691.

Herrlinger U, Jones DT, Glas M, Hattingen E, Gramatzki D, Stuplich M, Felsberg J, Bähr O, Gielen GH, Simon M, Wiewrodt D, Schabet M, Hovestadt V, Capper D, Steinbach JP, von Deimling A, Lichter P, Pfister SM, Weller M, Reifenberger G. Gliomatosis cerebri: no evidence for a separate brain tumor entity. Acta Neuropathol. 2016 Feb;131(2):309-19. doi: 10.1007/s00401-015-1495-z. Erratum in: Acta Neuropathol. 2016 Feb;131(2):321-2. PMID: 26493382

Kaut O, Becker B, Schneider C, Zhou F, Fliessbach K, Hurlemann R, Wüllner U. Stochastic resonance therapy induces increased movement related caudate nucleus activity. J Rehabil Med. 2016 Oct 12;48(9):815-818. doi: 10.2340/16501977-2143. PubMed PMID: 27671247.

Kaut O, Brenig D, Marek M, Allert N, Wüllner U. Postural Stability in Parkinson's Disease Patients Is Improved after Stochastic Resonance Therapy. Parkinsons Dis. 2016;2016:7948721. doi: 10.1155/2016/7948721. PubMed PMID: 26925293; PubMed Central PMCID: PMC4746396.

Kebir S, Fimmers R, Galldiks N, Schäfer N, Mack F, Schaub C, Stuplich M, Niessen M, Tzaridis T, Simon M, Stoffels G, Langen KJ, Scheffler B, Glas M, Herrlinger U. Late Pseudoprogression in Glioblastoma: Diagnostic Value of Dynamic O-(2-[18F]fluoroethyl)-L-Tyrosine PET. Clin Cancer Res. 2016 May 1;22(9):2190-6. doi: 10.1158/1078-0432.CCR-15-1334.

Kebir S, Gaertner FC, Mueller M, Nelles M, Simon M, Schäfer N, Stuplich M, Schaub C, Niessen M, Mack F, Bundschuh R, Greschus S, Essler M, Glas M, Herrlinger U. 18F-fluoroethyl-L-tyrosine positron emission tomography for the differential diagnosis of tumefactive multiple sclerosis versus glioma: A case report. Oncol Lett. 2016 Mar;11(3):2195-2198.

Kebir S, Rauschenbach L, Galldiks N, Schlaak M, Hattingen E, Landsberg J, Bundschuh RA, Langen KJ, Scheffler B, Herrlinger U, Glas M. Dynamic O-(2-[18F]fluoroethyl)-L-tyrosine PET imaging for the detection of checkpoint inhibitor-related pseudoprogression in melanoma brain metastases. Neuro Oncol. 2016 Oct;18(10):1462-4. doi: 10.1093/neuonc/now154. PMID: 27591333

Korfel A, Schlegel U, Herrlinger U, Dreyling M, Schmidt C, von Baumgarten L, Pezzutto A, Grobosch T, Kebir S, Thiel E, Martus P, Kiewe P. Phase II Trial of Temsirolimus for Relapsed/Refractory Primary CNS Lymphoma. J Clin Oncol. 2016 May 20;34(15):1757-63. doi: 10.1200/JCO.2015.64.9897. PMID: 26976424

Liu H, Li X, Ning G, Zhu S, Ma X, Liu X, Liu C, Huang M, Schmitt I, Wüllner U, Niu Y, Guo C, Wang Q, Tang TS. The Machado- Joseph Disease Deubiquitinase Ataxin-3 Regulates the Stability and Apoptotic Function of p53. PLoS Biol. 2016 Nov 16;14(11):e2000733. doi: 10.1371/journal.pbio.2000733. PubMed PMID: 27851749; PubMed Central PMCID: PMC5112960.

Mack F, Baumert BG, Schäfer N, Hattingen E, Scheffler B, Herrlinger U, Glas M. Therapy of leptomeningeal metastasis in solid tumors. Cancer Treat Rev. 2016 Feb;43:83-91. doi: 10.1016/j.ctrv.2015.12.004. Review.

Major S, Petzold GC, Reiffurth C, Windmüller O, Foddis M, Lindauer U, Kang EJ, Dreier JP. A role of the sodium pump in spreading ischemia in rats. J Cereb Blood Flow Metab. 2016 Mar 18. pii: 0271678X16639059. [Epub ahead of print] PubMed PMID: 26994042.

Mengel D, Dams J, Ziemek J, Becker J, Balzer-Geldsetzer M, Hilker R, Baudrexel S, Kalbe E, Schmidt N, Witt K, Liepelt-Scarfone I, Gräber S, Petrelli A, Neuser P, Schulte C, Linse K, Storch A, Wittchen HU, Riedel O, Mollenhauer B, Ebentheuer J, Trenkwalder C, Klockgether T, Spottke A, Wüllner U, Schulz JB, Reetz K, Heber IA, Ramirez A, Dodel R. Apolipoprotein E ε4 does not affect cognitive performance in patients with Parkinson's disease. Parkinsonism Relat Disord. 2016 Aug;29:112-6. doi: 10.1016/j.parkreldis.2016.04.013. PubMed PMID: 27321987.

Mochmann HC, Scheitz JF, Petzold GC, Haeusler KG, Audebert HJ, Laufs U, Schneider C, Landmesser U, Werner N, Endres M, Witzenbichler B, Nolte CH; TRELAS Study Group. . Coronary Angiographic Findings in Acute Ischemic Stroke Patients With Elevated Cardiac Troponin: The Troponin Elevation in Acute Ischemic Stroke (TRELAS) Study. Circulation. 2016 Mar 29;133(13):1264-71. doi: 10.1161/CIRCULATIONAHA.115.018547. PubMed PMID: 26933082.

Rakers C, Petzold GC. Astrocytic calcium release mediates peri-infarct depolarizations in a rodent stroke model. J Clin Invest. 2017 Feb 1;127(2):511-516. doi: 10.1172/JCI89354. PubMed PMID: 27991861; PubMed Central PMCID: PMC5272189.

Saggu R, Schumacher T, Gerich F, Rakers C, Tai K, Delekate A, Petzold GC. Astroglial NF-kB contributes to white matter damage and cognitive impairment in a mouse model of vascular dementia. Acta Neuropathol Commun. 2016 Aug 4;4(1):76. doi: 10.1186/s40478-016-0350-3. PubMed PMID: 27487766; PubMed Central PMCID: PMC4973061.

Sailer A, Scholz SW, Nalls MA, Schulte C, Federoff M, Price TR, Lees A, Ross OA, Dickson DW, Mok K, Mencacci NE, Schottlaender L, Chelban V, Ling H, O'Sullivan SS, Wood NW, Traynor BJ, Ferrucci L, Federoff HJ, Mhyre TR, Morris HR, Deuschl G, Quinn N, Widner H, Albanese A, Infante J, Bhatia KP, Poewe W, Oertel W, Höglinger GU, Wüllner U, Goldwurm S, Pellecchia MT, Ferreira J, Tolosa E, Schäfer N, Müller A, Wüllner U. Systemic Thrombolysis for Ischemic Stroke after Antagonizing Dabigatran with Idarucizumab-A Case Report. J Stroke Cerebrovasc Dis. 2016 Aug;25(8):e126-7. doi: 10.1016/j.jstrokecerebrovasdis.2016.05.006. PubMed PMID: 27236361.

Schäfer N, Gielen GH, Kebir S, Wieland A, Till A, Mack F, Schaub C, Tzaridis T, Reinartz R, Niessen M, Fimmers R, Simon M, Coch C, Fuhrmann C, Herrlinger U, Scheffler B, Glas M. Phase I trial of dovitinib (TKI258) in recurrent glioblastoma. J Cancer Res Clin Oncol. 2016 Jul;142 (7):1581-9. doi: 10.1007/s00432-016-2161-0.

Schaub C, Schäfer N, Mack F, Stuplich M, Kebir S, Niessen M, Tzaridis T, Banat M, Vatter H, Waha A, Herrlinger U, Glas M. The earlier the better? Bevacizumab in the treatment of recurrent MGMT-non-methylated glioblastoma. J Cancer Res Clin Oncol. 2016 Aug;142(8):1825-9. doi: 10.1007/s00432-016-2187-3.

Schaub C, Tichy J, Schäfer N, Franz K, Mack F, Mittelbronn M, Kebir S, Thiepold AL, Waha A, Filmann N, Banat M, Fimmers R, Steinbach JP, Herrlinger U, Rieger J, Glas M, Bähr O. Prognostic factors in recurrent glioblastoma patients treated with bevacizumab. J Neurooncol. 2016 Aug;129 (1):93-100. doi: 10.1007/s11060-016-2144-7.

Scholz A, Harter PN, Cremer S, Yalcin BH, Gurnik S, Yamaji M, Di Tacchio M, Sommer K, Baumgarten P, Bähr O, Steinbach JP, Trojan J, Glas M, Herrlinger U, Krex D, Meinhardt M, Weyerbrock A, Timmer M, Goldbrunner R, Deckert M, Braun C, Schittenhelm J, Frueh JT, Ullrich E, Mittelbronn M, Plate KH, Reiss Y. Endothelial cell-derived angiopoietin-2 is a therapeutic target in treatment-naive and bevacizumab-resistant glioblastoma. EMBO Mol Med. 2015 Dec 14;8(1):39-57. doi: 10.15252/emmm.201505505. PMID: 26666269

Suchorska B, Weller M, Tabatabai G, Senft C, Hau P, Sabel MC, Herrlinger U, Ketter R, Schlegel U, Marosi C, Reifenberger G, Wick W, Tonn JC, Wirsching HG. Complete resection of contrast-enhancing tumor volume is associated with improved survival in recurrent glioblastoma-results from the DIRECTOR trial. Neuro Oncol. 2016 Apr;18(4):549-56. doi: 10.1093/neuonc/nov326. PMID: 268235033.

Weller J, Steinhäuser C, Seifert G. pH-Sensitive K(+) Currents and Properties of K2P Channels in Murine Hippocampal Astrocytes. Adv Protein Chem Struct Biol. 2016;103:263-94. doi:10.1016/bs.apcsb.2015.10.005. PubMed PMID: 26920692.

Winter L, Wittig I, Peeva V, Eggers B, Heidler J, Chevessier F, Kley RA, Barkovits K, Strecker V, Berwanger C, Herrmann H, Marcus K, Kornblum C, Kunz WS, Schröder R, Clemen CS. Mutant desmin substantially perturbs mitochondrial morphology, function and maintenance in skeletal muscle tissue. Acta Neuropathol. 2016 Sep;132(3):453-73. doi: 10.1007/s00401-016-1592-7. PubMed PMID: 27393313; PubMed Central PMCID: PMC4992032.

Winter L, Türk M, Harter PN, Mittelbronn M, Kornblum C, Norwood F, Jungbluth H, Thiel CT, Schlötzer-Schrehardt U, Schröder R. Downstream effects of plectin mutations in epidermolysis bullosa simplex with muscular dystrophy. Acta Neuropathol Commun. 2016 Apr 27;4(1):44. doi: 10.1186/s40478-016-0314-7. PubMed PMID: 27121971; PubMed Central PMCID: PMC4847350.

Wüllner U. [Epigenetics in Parkinson's Disease]. Fortschr Neurol Psychiatr. 2016 Jul;84 Suppl 1:S3-7. doi: 10.1055/s-0042- 104501. German. PubMed PMID: 27299943.

Wüllner U, Kaut O, deBoni L, Piston D, Schmitt I. DNA methylation in Parkinson's disease. J Neurochem. 2016 Oct;139 Suppl 1:108 -120. doi: 10.1111/jnc.13646. Review. PubMed PMID: 27120258.