Klinik und Poliklinik für Neurologie

Forschung

In unserer Abteilung forschen mehrere Gruppen über die möglichen Ursachen neurodegenerativer Krankheiten und bearbeiten dabei auch verschiedene klinische und vorklinische Aspekte:

Vorklinisch / Grundlagenwissenschaften
ALZHEIMER Prof. J. Walter
ATAXIE PD Dr.P. Breuer
EPIGENTIK PD Dr.B. Evert

Klinisch / Translational
ATAXIE Dr. J. Faber Dr. M. Grobe - Einsler
MIKROBIOM Dr. J. Bedarf
SPASTIK PD Dr. P. Tacik
Huntington / MND PD Dr. P. Weydt
MRgFUS Prof. Dr. U. Wüllner, Prof. H. Boecker (Lehrstuhl für Klinische Funktionelle Bildgebung Klinik für Diagnostische und Interventionelle Radiologie) [https://www.ukbonn.de/radiologie/forschung/klinische-funktionelle-bildgebung/] , Dr. V. Purrer, Dr. E. Pohl, Dr. C. Kindler
TPS Dr. A. Faikus

Unsere letzten wissenschaftlichen Veröffentlichungen

Markaki I, Bergström S, Tsitsi P, Remnestål J, Månberg A, Hertz E, Paslawski W, Sorjonen K, Uhlén M, Mangone G, Carvalho S, Rascol O, Meissner WG, Magnin E, Wüllner U, Corvol JC, Nilsson P, Svenningsson P. Cerebrospinal Fluid Levels of Kininogen-1 Indicate Early Cognitive Impairment in Parkinson's Disease. Mov Disord. 2020 Aug 15. doi: 10.1002/mds.28192. Online ahead of print. PMID: 33179332

Wüllner U. [Magnetic resonance tomography controlled focused ultrasound (MRgFUS) for tremor]. Fortschr Neurol Psychiatr. 2020 Sep;88(9):582-585. doi: 10.1055/a-1227-6211. Epub 2020 Sep 21. PMID: 32957143 Review. German.

Keil VC, Bakoeva SP, Jurcoane A, Doneva M, Amthor T, Koken P, Mädler B, Lüchters G, Block W, Wüllner U, Hattingen E. A pilot study of magnetic resonance fingerprinting in Parkinson's disease. NMR Biomed. 2020 Nov;33(11):e4389. doi: 10.1002/nbm.4389. Epub 2020 Aug 11. PMID: 32783321

Woitalla D, Krüger R, Lorenzl S, Müller T, Oelwein G, Storch A, Wolz M, Wüllner U. [The role of inhibitors of COMT and MAO-B in the therapy of Parkinson's disease]. Fortschr Neurol Psychiatr. 2020 Sep;88(9):620-633. doi: 10.1055/a-1149-9308. Epub 2020 Jun 25. PMID: 32588409 Review. German.

Sharma A, Weber D, Raupbach J, Dakal TC, Fließbach K, Ramirez A, Grune T, Wüllner U. Advanced glycation end products and protein carbonyl levels in plasma reveal sex-specific differences in Parkinson's and Alzheimer's disease. Redox Biol. 2020 Jul;34:101546. doi: 10.1016/j.redox.2020.101546. Epub 2020 May 18. PMID: 32460130 Free PMC article.

The Alpha-Synuclein Gene (SNCA) is a Genomic Target of Methyl-CpG Binding Protein 2 (MeCP2)-Implications for Parkinson's Disease and Rett Syndrome. Schmitt I, Evert BO, Sharma A, Khazneh H, Murgatroyd C, Wüllner U. Mol Neurobiol. 2024 Mar 2. doi: 10.1007/s12035-024-03974-3. Online ahead of print. PMID: 38429622

Automatic planning of MR-guided transcranial focused ultrasound treatment for essential tremor. Klein J, Gerken A, Agethen N, Rothlübbers S, Upadhyay N, Purrer V, Schmeel C, Borger V, Kovalevsky M, Rachmilevitch I, Shapira Y, Wüllner U, Jenne J. Front Neuroimaging. 2023 Oct 26;2:1272061. doi: 10.3389/fnimg.2023.1272061. eCollection 2023. PMID: 37953746Free PMC article.

Artificial-intelligence-based MRI brain volumetry in patients with essential tremor and tremor-dominant Parkinson's disease. Purrer V, Pohl E, Lueckel JM, Borger V, Sauer M, Radbruch A, Wüllner U, Schmeel FC. Brain Commun. 2023 Oct 13;5(6):fcad271. doi: 10.1093/braincomms/fcad271. eCollection 2023. PMID: 37946794Free PMC article.

Increased diversity of Malassezia species on the skin of Parkinson's disease patients. Han X, Bedarf J, Proske-Schmitz S, Schmitt I, Wüllner U. Front Aging Neurosci. 2023 Oct 3;15:1268751. doi: 10.3389/fnagi.2023.1268751. eCollection 2023. PMID: 37854034Free PMC article.

No evidence for neuronal damage or astrocytic activation in cerebrospinal fluid of Neuro-COVID-19 patients with long-term persistent headache. de Boni L, Odainic A, Gancarczyk N, Kaluza L, Strassburg CP, Kersting XAK, Wüllner U, Schmidt SV, Petzold GC. Neurol Res Pract. 2023 Sep 28;5(1):49. doi: 10.1186/s42466-023-00277-1. PMID: 37759276Free PMC article.

MRgFUS of the nucleus ventralis intermedius in essential tremor modulates functional connectivity within the classical tremor network and beyond. Kindler C, Upadhyay N, Purrer V, Schmeel FC, Borger V, Scheef L, Wüllner U, Boecker H. Parkinsonism Relat Disord. 2023 Oct;115:105845. doi: 10.1016/j.parkreldis.2023.105845. Epub 2023 Sep 12. PMID: 37717502

High throughput compound screening in neuronal cells identifies statins as activators of ataxin 3 expression. Stahl F, Schmitt I, Denner P, de Boni L, Wüllner U, Breuer P. Sci Rep. 2023 Sep 9;13(1):14911. doi: 10.1038/s41598-023-41192-4. PMID: 37689718Free PMC article.

Downregulation of MGMT expression by targeted editing of DNA methylation enhances temozolomide sensitivity in glioblastoma. Han X, Abdallah MOE, Breuer P, Stahl F, Bakhit Y, Potthoff AL, Pregler BEF, Schneider M, Waha A, Wüllner U, Evert BO. Neoplasia. 2023 Oct;44:100929. doi: 10.1016/j.neo.2023.100929. Epub 2023 Aug 25. PMID: 37634280Free PMC article.

Genome-wide association study identifies a new susceptibility locus in PLA2G4C for Multiple System Atrophy. Nakahara Y, Mitsui J, Date H, Porto KJ, Hayashi Y, Yamashita A, Kusakabe Y, Matsukawa T, Ishiura H, Yasuda T, Iwata A, Goto J, Ichikawa Y, Momose Y, Takahashi Y, Toda T, Ohta R, Yoshimura J, Morishita S, Gustavsson EK, Christy D, Maczis M, Farrer MJ, Kim HJ, Park SS, Jeon B, Zhang J, Gu W, Scholz SW, Singleton AB, Houlden H, Yabe I, Sasaki H, Matsushima M, Takashima H, Kikuchi A, Aoki M, Hara K, Kakita A, Yamada M, Takahashi H, Onodera O, Nishizawa M, Watanabe H, Ito M, Sobue G, Ishikawa K, Mizusawa H, Kanai K, Kuwabara S, Arai K, Koyano S, Kuroiwa Y, Hasegawa K, Yuasa T, Yasui K, Nakashima K, Ito H, Izumi Y, Kaji R, Kato T, Kusunoki S, Osaki Y, Horiuchi M, Yamamoto K, Shimada M, Miyagawa T, Kawai Y, Nishida N, Tokunaga K, Dürr A, Brice A, Filla A, Klockgether T, Wüllner U, Tanner CM, Kukull WA, Lee VM, Masliah E, Low PA, Sandroni P, Ozelius L, Foroud T, Tsuji S. medRxiv [Preprint]. 2023 May 2:2023.05.02.23289328. doi: 10.1101/2023.05.02.23289328. PMID: 37425910Free PMC article.Preprint.

The heterogeneity of Parkinson's disease. Wüllner U, Borghammer P, Choe CU, Csoti I, Falkenburger B, Gasser T, Lingor P, Riederer P. J Neural Transm (Vienna). 2023 Jun;130(6):827-838. doi: 10.1007/s00702-023-02635-4. Epub 2023 May 11. PMID: 37169935Free PMC article.Review.