Klinik und Poliklinik für Neurologie

Publikationen 2011

Acaster S, Swinburn P, Wang C, Stemper B, Beckmann K, Knappertz V, Pohl C, Sandbrink R, Gondek K, Edan G, Kappos L, Freedman M, Hartung HP, Arnason B, Comi G, Filippi M, Jeffery D, O'Connor P, Cook S, Lloyd AJ. Can the functional assessment of multiple sclerosis adapt to changing needs? A psychometric validation in patients with clinically isolated syndrome and early relapsing-remitting multiple sclerosis. Mult Scler. 2011;17(12):1504-13.

Allert N, Kelm D, Spottke A, Coenen VA. Role of dysphagia in evaluating Parkinson patients for subthalamic nucleus stimulation: a case report. J Neural Transm. 2011;118(9):1345-8.

Araujo J, Breuer P, Dieringer S, Krauss S, Dorn S, Zimmermann K, Pfeifer A, Klockgether T, Wuellner U, Evert BO. FOXO4-dependent upregulation of superoxide dismutase-2 in response to oxidative stress is impaired in spinocerebellar ataxia type 3. Hum Mol Genet. 2011;20(15):2928-41.

Balzer-Geldsetzer M, da Costa ASFB, Kronenburger M, Schulz JB, Roske S, Spottke A, Wullner U, Klockgether T, Storch A, Schneider C, Riedel O, Wittchen HU, Seifried C, Hilker R, Schmidt N, Witt K, Deuschl G, Mollenhauer B, Trenkwalder C, Liepelt-Scarfone I, Graber-Sultan S, Berg D, Gasser T, Kalbe E, Bodden M, Oertel WH, Dodel R. Parkinson's Disease and Dementia: A Longitudinal Study (DEMPARK). Neuroepidemiology. 2011;37(3-4):168-76.

Erk S, Spottke A, Meisen A, Wagner M, Walter H, Jessen F. Evidence of neuronal compensation during episodic memory in subjective memory impairment. Arch Gen Psychiatry. 2011;68(8):845-52.

Filippi M, Rocca MA, Camesasca F, Cook S, O'Connor P, Arnason BG, Kappos L, Goodin D, Jeffery D, Hartung HP, Comi G, Wolinsky JS, Bogumil T, Pohl C, Beckmann K, Sandbrink R, Croze E, Brown C, Desimone TM, Arnold DL, Cutter G, Knappertz V. Interferon beta-1b and glatiramer acetate effects on permanent black hole evolution. Neurology. 2011;76(14):1222-8.

Glas M, Bähr O, Felsberg J, Rasch K, Wiewrodt D, Schabet M, Simon M, Urbach H, Steinbach JP, Rieger J, Fimmers R, Bamberg M, Nägele T, Reifenberger G, Weller M, Herrlinger U, Neuro-Oncology Group of the German Cancer Society. NOA-05 phase 2 trial of procarbazine and lomustine therapy in gliomatosis cerebri. Ann Neurol. 2011;70(3):445-53.

Glebov K, Schütze S, Walter J. Functional relevance of a novel SlyX motif in non-conventional secretion of insulin-degrading enzyme. J Biol Chem. 2011;286(26):22711-5.

Hefter H, Kupsch A, Müngersdorf M, Paus S, Stenner A, Jost W, Dysport Cervical Dystonia Study Group , Eing H, Plewe A, Patzner B, Griese H, Pott M, Nebe A, Winter T, Wissel J, Woldag H, Raffauf W, Tiel-Wilck K, Garcia AM, Gruber D, Kempf F, Krug H, Lobsien E, Leistner S, Schenkel-Römer A, Eue S, Bonse M, Nastos I, Otto O, Grehl T, Tegenthoff M, Ebke M, Kunesch E, Probst T, Richter M, Hermann A, Wolz M, Kahlen U, Moll M, Grüger A, Feise P, Kölmel HW, Kotthaus L, Haslbeck M, Jaspert-Grehl A, Maschke M, Obermann M, Putzki N, Böhm J, Schiel C, Hahn M, Reuter I, Schmidt S, Krumpolt H, Brake FM, Hoffman F, Wohlrab C, Becker V, Humbert T, Mohammadi B, Dengler R, Kollewe K, Krampfl K, Petri S, Osterhage J, Müller D, Gehring K, Heide G, Jentsch A, Morganthaler M, Volkmann J, Marczynski U, Wöhrle J, Wittman B, Peschel S, Baum P, Schneider R, Hagenah J, Bohr KA, Bäzner H, Blahak C, Philipps J, Althoff R, Haan J, Kessler K, Castrop F, Dresel D, Esposito L, Loer C, Haslinger B, Ceballos-Baumann AO, Fietzek U, Messner M, Riedl L, Ritter M, Young P, Erbguth F, Witte R, Putzer M, Kursawe H, Sutterheim K, Vollmer-Haase J, Benecke R, Schöffel M, Fleischer E, Nguento A, Warmecke T, Roick H, Petrick M, Hahn J, Fucik F, Heitmann S, Zeiler B, Cordes P, Schierenbeck J, Helbig C, Klein M, Oehler KU, Beck M, Schramm A, Hennen G, Reichel G, Diez J, Schnider P, Haydn T, Müller J, Poewe W, Resch RJ, Sommer R. A botulinum toxin A treatment algorithm for de novo management of torticollis and laterocollis. BMJ Open. 2011;1(2):e000196.

Heneka MT, Kummer MP, Weggen S, Bulic B, Multhaup G, Münter L, Hüll M, Pflanzner T, Pietrzik CU. Molecular mechanisms and therapeutic application of NSAIDs and derived compounds in Alzheimer's disease. Curr Alzheimer Res. 2011;8(2):115-31.

Hoche F, Balikó L, den Dunnen W, Steinecker K, Bartos L, Sáfrány E, Auburger G, Deller T, Korf HW, Klockgether T, Rüb U, Melegh B. Spinocerebellar ataxia type 2 (SCA2): identification of early brain degeneration in one monozygous twin in the initial disease stage. Cerebellum. 2011;10(2):245-53.

Hübener J, Vauti F, Funke C, Wolburg H, Ye Y, Schmidt T, Wolburg-Buchholz K, Schmitt I, Gardyan A, Driessen S, Arnold HH, Nguyen HP, Riess O. N-terminal ataxin-3 causes neurological symptoms with inclusions, endoplasmic reticulum stress and ribosomal dislocation. Brain. 2011;134(Pt 7):1925-42.

Ip JPK, Nocon AL, Hofer MJ, Lim SL, Muller M, Campbell IL. Lipocalin 2 in the central nervous system host response to systemic lipopolysaccharide administration. J Neuroinflammation. 2011;8:124.

Jacobi H, Bauer P, Giunti P, Labrum R, Sweeney MG, Charles P, Dürr A, Marelli C, Globas C, Linnemann C, Schöls L, Rakowicz M, Rola R, Zdzienicka E, Schmitz-Hübsch T, Fancellu R, Mariotti C, Tomasello C, Baliko L, Melegh B, Filla A, Rinaldi C, van de Warrenburg BP, Verstappen CC, Szymanski S, Berciano J, Infante J, Timmann D, Boesch S, Hering S, Depondt C, Pandolfo M, Kang JS, Ratzka S, Schulz J, Tezenas du Montcel S, Klockgether T. The natural history of spinocerebellar ataxia type 1, 2, 3, and 6: a 2-year follow-up study. Neurology. 2011;77(11):1035-41.

Jardanhazi-Kurutz D, Kummer MP, Terwel D, Vogel K, Thiele A, Heneka MT. Distinct adrenergic system changes and neuroinflammation in response to induced locus ceruleus degeneration in APP/PS1 transgenic mice. Neuroscience. 2011;176:396-407.

Jeub M, Jeub M, Emrich M, Pradier B, Taha O, Gailus-Durner V, Fuchs H, de Angelis MH, Huylebroeck D, Zimmer A, Beck H, Racz I. The transcription factor Smad-interacting protein 1 controls pain sensitivity via modulation of DRG neuron excitability. Pain. 2011;152(10):2384-98.

Juckel G, Manitz MP, Brüne M, Friebe A, Heneka MT, Wolf RJ. Microglial activation in a neuroinflammational animal model of schizophrenia--a pilot study. Schizophr Res. 2011;131(1-3):96-100.

Kalbe E, Onur OA, Minnerop M, Reimann J, Althaus A, Ahmadzadehfar H, Dodel R, Strach K, Clemen CS, Herholz K, Haense C, Fink GR, Schröder R. Early signs of VCP-related frontotemporal dementia: a neuropsychological, FDG-PET and fMRI study. J Neurol. 2011;258(3):515-8.

Kaut O, Allert N, Coch C, Paus S, Grzeska A, Minnerop M, Wüllner U. Stochastic resonance therapy in Parkinson's disease. NeuroRehabilitation. 2011;28(4):353-8.

Kilger E, Buehler A, Woelfing H, Kumar S, Kaeser SA, Nagarathinam A, Walter J, Jucker M, Coomaraswamy J. BRI2 protein regulates beta-amyloid degradation by increasing levels of secreted insulin-degrading enzyme (IDE). J Biol Chem. 2011;286(43):37446-57.

Klein C, Hagenah J, Landwehrmeyer B, Münte T, Klockgether T. [The presymptomatic stage of neurodegenerative disorders]. Nervenarzt. 2011;82(8):994-1001.

Klockgether T. Update on degenerative ataxias. Curr Opin Neurol. 2011;24(4):339-45.

Klockgether T, Paulson H. Milestones in ataxia. Mov Disord. 2011;26(6):1134-41.

Koch P, Breuer P, Peitz M, Jungverdorben J, Kesavan J, Poppe D, Doerr J, Ladewig J, Mertens J, Tüting T, Hoffmann P, Klockgether T, Evert BO, Wüllner U, Brüstle O. Excitation-induced ataxin-3 aggregation in neurons from patients with Machado-Joseph disease. Nature. 2011;480(7378):543-6.

Kornblum C, Reimann J, Wattjes MP. Response: skeletal muscle MRI in recessive myotonia congenita. Acta Neurol Scand. 2011;124(2):148.

Krauthausen M, Ellis SL, Zimmermann J, Sarris M, Wakefield D, Heneka MT, Campbell IL, Müller M. Opposing roles for CXCR3 signaling in central nervous system versus ocular inflammation mediated by the astrocyte-targeted production of IL-12. Am J Pathol. 2011;179(5):2346-59.

Kumar S, Rezaei-Ghaleh N, Terwel D, Thal DR, Richard M, Hoch M, Mc Donald JM, Wüllner U, Glebov K, Heneka MT, Walsh DM, Zweckstetter M, Walter J. Extracellular phosphorylation of the amyloid beta-peptide promotes formation of toxic aggregates during the pathogenesis of Alzheimer's disease. EMBO J. 2011;30(11):2255-65.

Kumar S, Walter J. Phosphorylation of amyloid beta (Abeta) peptides - a trigger for formation of toxic aggregates in Alzheimer's disease. Aging (Albany NY). 2011;3(8):803-12.

Kummer MP, Hermes M, Delekarte A, Hammerschmidt T, Kumar S, Terwel D, Walter J, Pape HC, König S, Roeber S, Jessen F, Klockgether T, Korte M, Heneka MT. Nitration of tyrosine 10 critically enhances amyloid beta aggregation and plaque formation. Neuron. 2011;71(5):833-44.

Lachenmayer ML, Blasius E, Niehusmann P, Kovacs A, Stuplich M, Eichler O, Glas M, Urbach H, Herrlinger U. Non-enhancing primary CNS lymphoma. J Neurooncol. 2011;101(2):343-4.

Lancaster E, Martinez-Hernandez E, Titulaer MJ, Boulos M, Weaver S, Antoine JC, Liebers E, Kornblum C, Bien CG, Honnorat J, Wong S, Xu J, Contractor A, Balice-Gordon R, Dalmau J. Antibodies to metabotropic glutamate receptor 5 in the Ophelia syndrome. Neurology. 2011;77(18):1698-701.

Legutko A, Marichal T, Fiévez L, Bedoret D, Mayer A, de Vries H, Klotz L, Drion PV, Heirman C, Cataldo D, Louis R, Thielemans K, Andris F, Leo O, Lekeux P, Desmet CJ, Bureau F. Sirtuin 1 promotes Th2 responses and airway allergy by repressing peroxisome proliferator-activated receptor-gamma activity in dendritic cells. J Immunol. 2011;187(9):4517-29.

Linnebank M, Moskau S, Semmler A, Widman G, Stoffel-Wagner B, Weller M, Elger CE. Antiepileptic drugs interact with folate and vitamin B12 serum levels. Ann Neurol. 2011;69(2):352-9.

Linnebank M, Moskau S, Semmler A, Widman G, Stoffel-Wagner B, Weller M, Elger CE. Vitamin B12, Folate and Hyperhomocysteinemia in Patients with Epilepsy Reply. Ann Neurol. 2011;69(6):1068.

Mattsson N, Andreasson U, Persson S, Arai H, Batish SD, Bernardini S, Bocchio-Chiavetto L, Blankenstein MA, Carrillo MC, Chalbot S, Coart E, Chiasserini D, Cutler N, Dahlfors G, Duller S, Fagan AM, Forlenza O, Frisoni GB, Galasko D, Galimberti D, Hampel H, Handberg A, Heneka MT, Herskovits AZ, Herukka SK, Holtzman DM, Humpel C, Hyman BT, Iqbal K, Jucker M, Kaeser SA, Kaiser E, Kapaki E, Kidd D, Klivenyi P, Knudsen CS, Kummer MP, Lui J, Lladó A, Lewczuk P, Li QX, Martins R, Masters C, McAuliffe J, Mercken M, Moghekar A, Molinuevo JL, Montine TJ, Nowatzke W, O'Brien R, Otto M, Paraskevas GP, Parnetti L, Petersen RC, Prvulovic D, de Reus HP, Rissman RA, Scarpini E, Stefani A, Soininen H, Schröder J, Shaw LM, Skinningsrud A, Skrogstad B, Spreer A, Talib L, Teunissen C, Trojanowski JQ, Tumani H, Umek RM, Van Broeck B, Vanderstichele H, Vecsei L, Verbeek MM, Windisch M, Zhang J, Zetterberg H, Blennow K. The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers. Alzheimers Dement. 2011;7(4):386-95.e6.

Mildner A, Schlevogt B, Kierdorf K, Böttcher C, Erny D, Kummer MP, Quinn M, Brück W, Bechmann I, Heneka MT, Priller J, Prinz M. Distinct and non-redundant roles of microglia and myeloid subsets in mouse models of Alzheimer's disease. J Neurosci. 2011;31(31):11159-71.

Minnerop M, Weber B, Schoene-Bake JC, Roeske S, Mirbach S, Anspach C, Schneider-Gold C, Betz RC, Helmstaedter C, Tittgemeyer M, Klockgether T, Kornblum C. The brain in myotonic dystrophy 1 and 2: evidence for a predominant white matter disease. Brain. 2011;134:3527-43.

Müller M, Hemicker G, Jüptner U, Wuellner U, Wirtz DC, Hirner A, Standop J. [Inadequate reimbursement for surgical patients with Parkinson's disease according to diagnosis-related grouping]. Zentralbl Chir. 2011;136(2):168-71.

Niehusmann P, Surges R, von Wrede RD, Elger CE, Wellmer J, Reimann J, Urbach H, Vielhaber S, Bien CG, Kunz WS. Mitochondrial dysfunction due to Leber's hereditary optic neuropathy as a cause of visual loss during assessment for epilepsy surgery. Epilepsy Behav. 2011;20(1):38-43.

Paus S, Gross J, Moll-Müller M, Hentschel F, Spottke A, Wabbels B, Klockgether T, Abele M. Impaired sleep quality and restless legs syndrome in idiopathic focal dystonia: a controlled study. J Neurol. 2011;258(10):1835-40.

Perez Nievas BG, Hammerschmidt T, Kummer MP, Terwel D, Leza JC, Heneka MT. Restraint stress increases neuroinflammation independently of amyloid beta levels in amyloid precursor protein/PS1 transgenic mice. J Neurochem. 2011;116(1):43-52.

Petzold GC, Murthy VN. Role of astrocytes in neurovascular coupling. Neuron. 2011;71(5):782-97.

Reilich P, Horvath R, Krause S, Schramm N, Turnbull DM, Trenell M, Hollingsworth KG, Gorman GS, Hans VH, Reimann J, MacMillan A, Turner L, Schollen A, Witte G, Czermin B, Holinski-Feder E, Walter MC, Schoser B, Lochmüller H. The phenotypic spectrum of neutral lipid storage myopathy due to mutations in the PNPLA2 gene. J Neurol. 2011;258(11):1987-97.

Reimann J, Kornblum C, Tolksdorf K, Brück W, van Landeghem FK. Myopathy and neuropathy with pipestem capillaries and vascular activated complement deposition. Neurology. 2011;77(4):401-3.

Sabet A, Ahmadzadehfar H, Herrlinger U, Wilinek W, Biersack HJ, Ezziddin S. Successful radiopeptide targeting of metastatic anaplastic meningioma: case report. Radiat Oncol. 2011;6:94.

Sajonz B, Mädler B, Herberhold S, Paus S, Coenen VA. A case of tremor reduction and almost complete ageusia under bilateral thalamic (VIM) deep brain stimulation in essential tremor--a therapeutic dilemma. Acta Neurochir (Wien). 2011;153(12):2361-3.

Schaefer N, Rasch K, Moehlenbruch M, Urbach H, Stuplich M, Blasius E, Scheffler B, Herrlinger U, Glas M. Leptomeningeal melanomatosis: stabilization of disease due to radiation, temozolomide and intrathecal liposomal cytarabine. Acta Oncol. 2011;50(8):1260-2.

Schäfer N, Tichy J, Thanendrarajan S, Kim Y, Stuplich M, Mack F, Rieger J, Simon M, Scheffler B, Boström J, Steinbach JP, Herrlinger U, Glas M. Ifosfamide, carboplatin and etoposide in recurrent malignant glioma. Oncology. 2011;80(5-6):330-2.

Schmitz-Hübsch T, Coudert M, Tezenas du Montcel S, Giunti P, Labrum R, Dürr A, Ribai P, Charles P, Linnemann C, Schöls L, Rakowicz M, Rola R, Zdzienicka E, Fancellu R, Mariotti C, Baliko L, Melegh B, Filla A, Salvatore E, van de Warrenburg BP, Szymanski S, Infante J, Timmann D, Boesch S, Depondt C, Kang JS, Schulz JB, Klopstock T, Lossnitzer N, Löwe B, Frick C, Rottländer D, Schlaepfer TE, Klockgether T. Depression comorbidity in spinocerebellar ataxia. Mov Disord. 2011;26(5):870-6.

Schwarz J, Odin P, Buhmann C, Csoti I, Jost W, Wüllner U, Storch A. Depression in Parkinson's disease. J Neurol. 2011;258(Suppl 2):S336-8.

Spottke A, Schneider F, Dodel R. [Benchmarking in patient care: depression in Parkinson's disease]. Z Evid Fortbild Qual Gesundhwes. 2011;105(5):383-8.

Steinbeck JA, Stuplich M, Blasius E, Pels H, Glas M, Schlegel U, Herrlinger U. Relapse of primary central nervous system lymphoma 13 years after high-dose methotrexate-based polychemotherapy. J Clin Neurosci. 2011;18(11):1554-5.

Striepens N, Scheef L, Wind A, Meiberth D, Popp J, Spottke A, Kölsch H, Wagner M, Jessen F. Interaction effects of subjective memory impairment and ApoE4 genotype on episodic memory and hippocampal volume. Psychol Med. 2011;41(9):1997-2006.

Synofzik M, Beetz C, Bauer C, Bonin M, Sanchez-Ferrero E, Schmitz-Hübsch T, Wüllner U, Nägele T, Riess O, Schöls L, Bauer P. Spinocerebellar ataxia type 15: diagnostic assessment, frequency, and phenotypic features. J Med Genet. 2011;48(6):407-12.

Tamboli IY, Hampel H, Tien NT, Tolksdorf K, Breiden B, Mathews PM, Saftig P, Sandhoff K, Walter J. Sphingolipid storage affects autophagic metabolism of the amyloid precursor protein and promotes Abeta generation. J Neurosci. 2011;31(5):1837-49.

Tamboli IY, Tien NT, Walter J. Sphingolipid storage impairs autophagic clearance of Alzheimer-associated proteins. Autophagy. 2011;7(6):643-4.

Terwel D, Löschmann YN, Schmidt HH, Schöler HR, Cantz T, Heneka MT. Neuroinflammatory and behavioural changes in the Atp7B mutant mouse model of Wilson's disease. J Neurochem. 2011;118(1):105-12.

Terwel D, Steffensen KR, Verghese PB, Kummer MP, Gustafsson JÅ, Holtzman DM, Heneka MT. Critical role of astroglial apolipoprotein E and liver X receptor-alpha expression for microglial Abeta phagocytosis. J Neurosci. 2011;31(19):7049-59.

Tschampa HJ, Greschus S, Vinahl M, Urbach H, Mueller MM, Gerding WM. MS-like presentation of Alexander disease with multifocal lesions and oligoclonal bands. J Neurol. 2011;258(5):935-7.

Ullrich ND, Fischer D, Kornblum C, Walter MC, Niggli E, Zorzato F, Treves S. Alterations of excitation-contraction coupling and excitation coupled Ca(2+) entry in human myotubes carrying CAV3 mutations linked to rippling muscle. Hum Mutat. 2011;32(3):309-17.

Waschbisch A, Sandbrink R, Hartung HP, Kappos L, Schwab S, Pohl C, Wiendl H. Evaluation of soluble HLA-G as a biomarker for multiple sclerosis. Neurology. 2011;77(6):596-8.

Winter Y, Spottke AE, Stamelou M, Cabanel N, Eggert K, Höglinger GU, Sixel-Doering F, Herting B, Klockgether T, Reichmann H, Oertel WH, Dodel R. Health-related quality of life in multiple system atrophy and progressive supranuclear palsy. Neurodegener Dis. 2011;8(6):438-46.

Winter Y, Stamelou M, Cabanel N, Sixel-Döring F, Eggert K, Höglinger GU, Herting B, Klockgether T, Reichmann H, Oertel WH, Dodel R, Spottke AE. Cost-of-illness in multiple system atrophy and progressive supranuclear palsy. J Neurol. 2011;258(10):1827-34.

Yue Z, Lachenmayer ML. Genetic LRRK2 models of Parkinson's disease: Dissecting the pathogenic pathway and exploring clinical applications. Mov Disord. 2011;26(8):1386-97.