Klinik und Poliklinik für Neurologie

Publikationen 2007

Abele M, Klockgether T. Health-related quality of life in sporadic adult-onset ataxia. Mov Disord. 2007;22(3):348-52.

Abele M, Minnerop M, Urbach H, Specht K, Klockgether T. Sporadic adult onset ataxia of unknown etiology: a clinical, electrophysiological and imaging study. J Neurol. 2007;254(10):1384-9.

Althaus A, Kanis T, Spottke A, Eggert K, Liepelt I, Berg D, Schneider F, Dodel R. Benchmarking in patient's care. Nervenheilkunde. 2007;26(4):277-80.

Barkhof F, Polman CH, Radue EW, Kappos L, Freedman MS, Edan G, Hartung HP, Miller DH, Montalbán X, Poppe P, de Vos M, Lasri F, Bauer L, Dahms S, Wagner K, Pohl C, Sandbrink R. Magnetic resonance imaging effects of interferon beta-1b in the BENEFIT study: integrated 2-year results. Arch Neurol. 2007;64(9):1292-8.

Becker A, Vezmar S, Linnebank M, Pels H, Bode U, Schlegel U, Jaehde U. Marked elevation in homocysteine and homocysteine sulfinic acid in the cerebrospinal fluid of lymphoma patients receiving intensive treatment with methotrexate. Int J Clin Pharmacol Ther. 2007;45(9):504-15.

Bös M, Grothe C, Urbach H, Schröder R. [Cerebellar syndromes in Langerhans' cell histiocytosis]. Nervenarzt. 2007;78(4):437-40.

Boes M, Urbach H, Klockgether T, Schlegel U. Persistent anarthria following mirror infarction in the anterior choroidal artery territory. Eur J Neurol. 2007;14(4):e6.

Braak H, Sastre M, Bohl JR, de Vos RA, Del Tredici K. Parkinson's disease: lesions in dorsal horn layer I, involvement of parasympathetic and sympathetic pre- and postganglionic neurons. Acta Neuropathol (Berl). 2007;113(4):421-9.

Braak H, Sastre M, Del Tredici K. Development of alpha-synuclein immunoreactive astrocytes in the forebrain parallels stages of intraneuronal pathology in sporadic Parkinson's disease. Acta Neuropathol (Berl). 2007;114(3):231-41.

Dodel R, Peter H, Spottke A, Noelker C, Althaus A, Siebert U, Walbert T, Kesper K, Becker HF, Mayer G. Health-related quality of life in patients with narcolepsy. Sleep Med. 2007;8(7-8):733-41.

Dodel R, Spottke A. Economic analysis of the Parkinson syndrome - Competence Network Parkinson. Nervenheilkunde. 2007;26(4):256-9.

Dombrowski F, Klotz L, Bannasch P, Evert M. Renal carcinogenesis in models of diabetes in rats: metabolic changes are closely related to neoplastic development. Diabetologia. 2007;50(12):2580-90.

Eggert K, Baas H, Deuschl G, Dode R, Franke S, Gasser T, Klockgether T. The Parkinson's expert network. Nervenheilkunde. 2007;26(4):239-40.

Eggert K, Wüllner U, Antony G, Gasser T, Janetzky B, Klein C, Schöls L, Oertel W. Data protection in biomaterial banks for Parkinson's disease research: the model of GEPARD (Gene Bank Parkinson's Disease Germany). Mov Disord. 2007;22(5):611-8.

Epifanov Y, Dodel R, Haacke C, Schaeg M, Schöffski O, Hennerici M, Back T. Costs of acute stroke care on regular neurological wards: a comparison with stroke unit setting. Health Policy. 2007;81(2-3):339-49.

Fischer D, Romero NB. Myopathic (not neuropathic) electrophysiologic abnormalities in dynamin 2-related centronuclear myopathy - Reply. Brain. 2007;130(Pt 2):E64.

Gao ZR, Kornblum C, Flacke S, Logvinski T, Yüksel M, An R, Klockgether T, Biersack HJ, Ezziddin S. Somatostatin receptor scintigraphy in the follow-up of myasthenia gravis. Neurol Sci. 2007;28(4):175-80.

Glas M, Koch H, Hirschmann B, Jauch T, Steinbrecher A, Herrlinger U, Bogdahn U, Hau P. Pegylated liposomal doxorubicin in recurrent malignant glioma: analysis of a case series. Oncology. 2007;72(5-6):302-7.

Glas M, Popp B, Angele B, Koedel U, Chahli C, Schmalix WA, Anneser JM, Pfister HW, Lorenzl S. A role for the urokinase-type plasminogen activator system in amyotrophic lateral sclerosis. Exp Neurol. 2007;207(2):350-6.

Goetz CG, Fahn S, Martinez-Martin P, Poewe W, Sampaio C, Stebbins GT, Stern MB, Tilley BC, Dodel R, Dubois B, Holloway R, Jankovic J, Kulisevsky J, Lang AE, Lees A, Leurgans S, LeWitt PA, Nyenhuis D, Olanow CW, Rascol O, Schrag A, Teresi JA, Van Hilten JJ, LaPelle N. Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS): Process, format, and clinimetric testing plan. Mov Disord. 2007;22(1):41-7.

Grimm SA, Pulido JS, Jahnke K, Schiff D, Hall AJ, Shenkier TN, Siegal T, Doolittle ND, Batchelor T, Herrlinger U, Neuwelt EA, Laperriere N, Chamberlain MC, Blay JY, Ferreri AJ, Omuro AM, Thiel E, Abrey LE. Primary intraocular lymphoma: an International Primary Central Nervous System Lymphoma Collaborative Group Report. Ann Oncol. 2007;18(11):1851-5.

Hübbers CU, Clemen CS, Kesper K, Böddrich A, Hofmann A, Kämäräinen O, Tolksdorf K, Stumpf M, Reichelt J, Roth U, Krause S, Watts G, Kimonis V, Wattjes MP, Reimann J, Thal DR, Biermann K, Evert BO, Lochmüller H, Wanker EE, Schoser BG, Noegel AA, Schröder R. Pathological consequences of VCP mutations on human striated muscle. Brain. 2007;130(Pt 2):381-93.

Jacobs AH, Rueger MA, Winkeler A, Li H, Vollmar S, Waerzeggers Y, Rueckriem B, Kummer C, Dittmar C, Klein M, Heneka MT, Herrlinger U, Fraefel C, Graf R, Wienhard K, Heiss WD. Imaging-guided gene therapy of experimental gliomas. Cancer Res. 2007;67(4):1706-15.

Kappos L, Freedman MS, Polman CH, Edan G, Hartung HP, Miller DH, Montalbán X, Barkhof F, Radü EW, Bauer L, Dahms S, Lanius V, Pohl C, Sandbrink R, BENEFIT Study Group. Effect of early versus delayed interferon beta-1b treatment on disability after a first clinical event suggestive of multiple sclerosis: a 3-year follow-up analysis of the BENEFIT study. Lancet. 2007;370(9585):389-97.

Kley RA, Hellenbroich Y, van der Ven PF, Fürst DO, Huebner A, Bruchertseifer V, Peters SA, Heyer CM, Kirschner J, Schröder R, Fischer D, Müller K, Tolksdorf K, Eger K, Germing A, Brodherr T, Reum C, Walter MC, Lochmüller H, Ketelsen UP, Vorgerd M. Clinical and morphological phenotype of the filamin myopathy: a study of 31 German patients. Brain. 2007;130(Pt 12):3250-64.

Klotz L, Dani I, Edenhofer F, Nolden L, Evert B, Paul B, Kolanus W, Klockgether T, Knolle P, Diehl L. Peroxisome proliferator-activated receptor gamma control of dendritic cell function contributes to development of CD4+ T cell anergy. J Immunol. 2007;178(4):2122-31.

Klotz L, Diehl L, Dani I, Neumann H, von Oppen N, Dolf A, Endl E, Klockgether T, Engelhardt B, Knolle P. Brain endothelial PPARgamma controls inflammation-induced CD4+ T cell adhesion and transmigration in vitro. J Neuroimmunol. 2007;190(1-2):34-43.

Kuhle J, Pohl C, Mehling M, Edan G, Freedman MS, Hartung HP, Polman CH, Miller DH, Montalban X, Barkhof F, Bauer L, Dahms S, Lindberg R, Kappos L, Sandbrink R. Lack of association between antimyelin antibodies and progression to multiple sclerosis. N Engl J Med. 2007;356(4):371-8.

Linnebank M, Malessa S, Moskau S, Semmler A, Pels H, Klockgether T, Schlegel U. Acute methotrexate-induced encephalopathy--causal relation to homozygous allelic state for MTR c.2756A>G (D919G)? J Chemother. 2007;19(4):455-7.

Lleo A, Galea E, Sastre M. Molecular targets of non-steroidal anti-inflammatory drugs in neurodegenerative diseases. Cell Mol Life Sci. 2007;64(11):1403-18.

Lutterbey G, Wattjes MP, Kandyba J, Harzheim M, Falkenhausen MV, Morakkabati N, Schild H, Gieseke J. Clinical evaluation of a speed optimized T2 weighted fast spin echo sequence at 3.0 T using variable flip angle refocusing, half-Fourier acquisition and parallel imaging. Br J Radiol. 2007;80(956):668-73.

Mi W, Pawlik M, Sastre M, Jung SS, Radvinsky DS, Klein AM, Sommer J, Schmidt SD, Nixon RA, Mathews PM, Levy E. Cystatin C inhibits amyloid-beta deposition in Alzheimer's disease mouse models. Nat Genet. 2007;39(12):1440-2.

Minnerop M, Specht K, Ruhlmann J, Schimke N, Abele M, Weyer A, Wüllner U, Klockgether T. Voxel-based morphometry and voxel-based relaxometry in multiple system atrophy-a comparison between clinical subtypes and correlations with clinical parameters. Neuroimage. 2007;36(4):1086-95.

Moskau S, Farmand S, Semmler A, Wüllner U, Pohl C, Klockgether T, Linnebank M. The methionine synthase polymorphism c.2756A>G (D919G) influences diastolic blood pressure. J Hum Hypertens. 2007;21(5):418-20.

Nielsen JM, Moraal B, Polman CH, Poppe P, de Vos M, Freedman MS, Kappos L, Barkhof F, Bauer L, Pohl C, Sandbrink R, Hartung HP, Uitdehaag BM. Classification of patients with a clinically isolated syndrome based on signs and symptoms is supported by magnetic resonance imaging results. Mult Scler. 2007;13(6):717-21.

Obermann M, Yaldizli O, De Greiff A, Lachenmayer ML, Buhl AR, Tumczak F, Gizewski ER, Diener HC, Maschke M. Morphometric changes of sensorimotor structures in focal dystonia. Mov Disord. 2007;22(8):1117-23.

Patt M, Solbach C, Wüllner U, Blocher A, Stahlschmidt A, Gündisch D, Kovar KA, Machulla HJ. Synthetic approaches and bio-distribution studies of [11C]methyl-phenidate. J Pharm Pharm Sci. 2007;10(2):312s-20s.

Paus S, Schmitz-Hübsch T, Wüllner U, Vogel A, Klockgether T, Abele M. Bright light therapy in Parkinson's disease: a pilot study. Mov Disord. 2007;22(10):1495-8.

Prager K, Wang-Eckhardt L, Fluhrer R, Killick R, Barth E, Hampel H, Haass C, Walter J. A structural switch of presenilin 1 by glycogen synthase kinase 3beta-mediated phosphorylation regulates the interaction with beta-catenin and its nuclear signaling. J Biol Chem. 2007;282(19):14083-93.

Reuther M, Spottke EA, Klotsche J, Riedel O, Peter H, Berger K, Athen O, Köhne-Volland R, Dodel RC. Assessing health-related quality of life in patients with Parkinson's disease in a prospective longitudinal study. Parkinsonism Relat Disord. 2007;13(2):108-14.

Rudnik-Schöneborn S, Botzenhart E, Eggermann T, Senderek J, Schoser BG, Schröder R, Wehnert M, Wirth B, Zerres K. Mutations of the LMNA gene can mimic autosomal dominant proximal spinal muscular atrophy. Neurogenetics. 2007;8(2):137-42.

Schmitt I, Linden M, Khazneh H, Evert BO, Breuer P, Klockgether T, Wuellner U. Inactivation of the mouse Atxn3 (ataxin-3) gene increases protein ubiquitination. Biochem Biophys Res Commun. 2007;362(3):734-9.

Schrag A, Dodel R, Spottke A, Bornschein B, Siebert U, Quinn NP. Rate of clinical progression in Parkinson's disease. A prospective study. Mov Disord. 2007;27(7):938-45.

Schreiner F, Hoppenz M, Klaeren R, Reimann J, Woelfle J. Novel COLQ mutation 950delC in synaptic congenital myasthenic syndrome and symptomatic heterozygous relatives. Neuromuscul Disord. 2007;17(3):262-5.

Semmler A, Frisch C, Debeir T, Ramanathan M, Okulla T, Klockgether T, Heneka MT. Long-term cognitive impairment, neuronal loss and reduced cortical cholinergic innervation after recovery from sepsis in a rodent model. Exp Neurol. 2007;204(2):733-40.

Semmler A, Klein A, Moskau S, Linnebank M. Transient global amnesia-like episode in a patient with severe hyperhomocysteinemia. Eur J Neurol. 2007;14(9):e5-6.

Semmler A, Kress W, Vielhaber S, Schröder R, Kornblum C. Variability of the recessive oculopharyngeal muscular dystrophy phenotype. Muscle Nerve. 2007;35(5):681-4.

Semmler A, Urbach H, Klockgether T, Linnebank M. Progressive multifocal leukoencephalopathy with selective involvement of the pyramidal tracts. Neurology. 2007;68(11):871.

Seyfried J, Wüllner U. Inhibition of thioredoxin reductase induces apoptosis in neuronal cell lines: role of glutathione and the MKK4/JNK pathway. Biochem Biophys Res Commun. 2007;359(3):759-64.

Thees C, Kaiser M, Scholz M, Semmler A, Heneka MT, Baumgarten G, Hoeft A, Putensen C. Cerebral haemodynamics and carbon dioxide reactivity during sepsis syndrome. Crit Care. 2007;11(6):R123.

Tzvetkov N, Breuer P. Josephin domain-containing proteins from a variety of species are active de-ubiquitination enzymes. Biol Chem. 2007;388(9):973-8.

Volk A, Karbasiyan M, Semmler A, Todt U, Urbach H, Klockgether T, Linnebank M. Adult index patient with Currarino syndrome due to a novel HLXB9 mutation, c.336dupG (p.P113fsX224), presenting with Hirschsprung's disease, cephalgia, and lumbodynia. Birth Defects Res A Clin Mol Teratol. 2007;79(3):249-51.

von der Brelie C, Kristof RA, Urbach H, Hartmann A, Hertfelder HJ, Putzsch B. Ischemic brain damage triggers overt disseminated intravascular coagulation in a young woman with cerebral venous sinus thrombosis. Thromb Haemost. 2007;98(6):1371-3.

Vyletal P, Sokolová J, Cooper DN, Kraus JP, Krawczak M, Pepe G, Rickards O, Koch HG, Linnebank M, Kluijtmans LA, Blom HJ, Boers GH, Gaustadnes M, Skovby F, Wilcken B, Wilcken DE, Andria G, Sebastio G, Naughten ER, Yap S, Ohura T, Pronicka E, Laszlo A, Kozich V. Diversity of cystathionine beta-synthase haplotypes bearing the most common homocystinuria mutation c.833T>C: a possible role for gene conversion. Hum Mutat. 2007;28(3):255-64.

Wattjes MP, Harzheim M, Lutterbey GG, Klotz L, Schild HH, Träber F. Axonal damage but no increased glial cell activity in the normal-appearing white matter of patients with clinically isolated syndromes suggestive of multiple sclerosis using high-field magnetic resonance spectroscopy. AJNR Am J Neuroradiol. 2007;28(8):1517-22.

Wattjes MP, Lutterbey GG, Gieseke J, Träber F, Klotz L, Schmidt S, Schild HH. Double inversion recovery brain imaging at 3T: diagnostic value in the detection of multiple sclerosis lesions. AJNR Am J Neuroradiol. 2007;28(1):54-9.

Weyer A, Abele M, Schmitz-Hübsch T, Schoch B, Frings M, Timmann D, Klockgether T. Reliability and validity of the scale for the assessment and rating of ataxia: a study in 64 ataxia patients. Mov Disord. 2007;22(11):1633-7.

Wick A, Felsberg J, Steinbach JP, Herrlinger U, Platten M, Blaschke B, Meyermann R, Reifenberger G, Weller M, Wick W. Efficacy and tolerability of temozolomide in an alternating weekly regimen in patients with recurrent glioma. J Clin Oncol. 2007;25(22):3357-61.

Wuellner U, Buhmann C, Hilker R, Hummel S, Korchounov A, Muller T, Paulus W, Schwartz A. Future therapeutic options in Parkinson's disease. Akt Neurol. 2007;34 Suppl:S18-S20.

Wüllner U, Franke S, Antony G, Eggert K. Gene Bank Parkinson's disease Germany (GEPARD), - a cooperative DNA-bank of patients with Parkinson's disease. Nervenheilkunde. 2007;26(4):246-50.

Wüllner U, Schmitz-Hübsch T, Abele M, Antony G, Bauer P, Eggert K. Features of probable multiple system atrophy patients identified among 4770 patients with parkinsonism enrolled in the multicentre registry of the German Competence Network on Parkinson's disease. J Neural Transm. 2007;114(9):1161-5.

Wüllner U, Schmitz-Hübsch T, Antony G, Fimmers R, Spottke A, Oertel WH, Deuschl G, Klockgether T, Eggert K, KNP e.V. Autonomic dysfunction in 3414 Parkinson's disease patients enrolled in the German Network on Parkinson's disease (KNP e.V.): the effect of ageing. Eur J Neurol. 2007;14(12):1405-8.

Zsurka G, Hampel KG, Kudina T, Kornblum C, Kraytsberg Y, Elger CE, Khrapko K, Kunz WS. Inheritance of mitochondrial DNA recombinants in double-heteroplasmic families: potential implications for phylogenetic analysis. Am J Hum Genet. 2007;80(2):298-305.