Klinik und Poliklinik für Neurologie

Sleep disorders and daytime sleepiness
in neurodegeneration

Our aims to investigate the interaction of sleep disorders in patients with neurodegenerative diseases.

As a key part of our research afford we participate in international clinical trials on potential new treatments for daytime sleepiness in patients with Parkinson’s Disease.

Additionally our research focusses on the treatment for narcolepsy and it socioeconomic effect.

Key Publications

Piper T, Mehling LM, Spottke A, Heidbreder A, Young P, Madea B, Hess C, Schänzer W, Thevis M. Potential of GHB phase-II-metabolites to complement current approaches in GHB post administration detection. Forensic Sci Int. 2017 Oct;279:157-164.

Paus S, Gross J, Moll-Müller M, Hentschel F, Spottke A, Wabbels B, Klockgether T, Abele M. Impaired sleep quality and restless legs syndrome in idiopathic focal dystonia: a controlled study. J Neurol. 2011 Oct;258(10):1835-40.

Riedel O, Klotsche J, Spottke A, Deuschl G, Förstl H, Henn F, Heuser I, Oertel W, Reichmann H, Riederer P, Trenkwalder C, Dodel R, Wittchen HU. Frequency of dementia, depression, and other neuropsychiatric symptoms in 1,449 outpatients with Parkinson's disease. J Neurol. 2010 Jul;257(7):1073-82.

Wüllner U, Schmitz-Hübsch T, Antony G, Fimmers R, Spottke A, Oertel WH, Deuschl G, Klockgether T, Eggert K. KNP e.V. Autonomic dysfunction in 3414 Parkinson's disease patients enrolled in the German Network on Parkinson's disease (KNP e.V.): the effect of ageing. Eur J Neurol. 2007 Dec;14(12):1405-8.

Dodel R, Peter H, Spottke A, Noelker C, Althaus A, Siebert U, Walbert T, Kesper K, Becker HF, Mayer G. Health-related quality of life in patients with narcolepsy. Sleep Med. 2007 Nov;8(7-8):733-41.

Möller JC, Körner Y, Dodel RC, Meindorfner C, Stiasny-Kolster K, Spottke A, Krüger HP, Oertel WH. Pharmacotherapy of Parkinson's disease in Germany. J Neurol. 2005 Aug;252(8):926-35.

Dodel R, Peter H, Walbert T, Spottke A, Noelker C, Berger K, Siebert U, Oertel WH, Kesper K, Becker HF, Mayer G. The socioeconomic impact of narcolepsy. Sleep. 2004 Sep 15;27(6):1123-8.

Dr. Annika Spottke
Dr. Annika Spottke


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