Klinik und Poliklinik für Neurologie

Neurovascular Diseases

Changes in cerebral blood flow are centrally involved in the pathogenesis of neurological diseases such as stroke, Alzheimer's disease and vascular dementia. However, the mechanisms underlying these changes remain incompletely understood. In addition, different classes of glial cells in the brain, such as astrocytes, undergo reactive inflammatory changes in these diseases, but the contribution of these pathways for neurodegeneration or neuroprotection have largely remained undefined.

We aim to identify the cellular signaling pathways responsible for blood flow regulation and reactive changes in glial cells, and their contribution to disease intitiation and progression. We investigate these questions in models of Alzheimer’s disease, vascular dementia, and stroke, using techniques such as in vivo two-photon microscopy, ultra-high field MRI, electropyhsiology, genetic and pharmacological calcium indicators, and behavioral tests.

In addition, we seek to translate our experimental findings into clinical studies. To this end, we are involved in the conception and execution of clinical multicenter studies investigating therapeutic strategies in stroke, as well as the mechanisms of vascular cognitive impairment.

Our work is funded by the German Center for Neurodegenerative Diseases (DZNE), Deutsche Forschungsgemeinschaft (DFG), Centres of Excellence in Neurodegeneration (CoEN), Else Kröner-Fresenius Stiftung (EKFS), and others.

Homepage: http://www.dzne.de/en/sites/bonn/research-groups/petzold.html

Publikationsliste (Pubmed): http://www.ncbi.nlm.nih.gov/pubmed/?term=petzold+gc


Key Publications

1: Singer OC, Haring HP, Trenkler J, Nolte CH, Bohner G, Reich A, Wiesmann M,Bussmeyer M, Mpotsaris A, Neumann-Haefelin T, Hohmann C, Niederkorn K,Deutschmann H, Stoll A, Bormann A, Jander S, Turowski B, Brenck J, Schlamann MU, Petzold GC, Urbach H, Liebeskind DS, Berkefeld J. Age dependency of successfulrecanalization in anterior circulation stroke: the ENDOSTROKE study. Cerebrovasc Dis. 2013;36(5-6):437-45. doi: 10.1159/000356213. Epub 2013 Nov 23. PubMed PMID: 24281318.

2: Singer OC, Haring HP, Trenkler J, Nolte CH, Bohner G, Neumann-Haefelin T,Hofmann E, Reich A, Wiesmann M, Niederkorn K, Deutschmann H, Bussmeyer M,Mpotsaris A, Stoll A, Bormann A, Petzold GC, Urbach H, Jander S, Turowski B,Weimar C, Schlamann M, Gröschel K, Boor S, Berkefeld J; ENDOSTROKE Study Group. Periprocedural aspects in mechanical recanalization for acute stroke: data fromthe ENDOSTROKE registry. Neuroradiology. 2013 Sep;55(9):1143-51. doi:10.1007/s00234-013- 1219-9. Epub 2013 Jun 28. PubMed PMID: 23811957.

3: Dreier JP, Victorov IV, Petzold GC, Major S, Windmüller O, Fernández-Klett F, Kandasamy M, Dirnagl U, Priller J. Electrochemical failure of the brain cortex ismore deleterious when it is accompanied by low perfusion. Stroke. 2013Feb;44(2):490-6. doi: 10.1161/STROKEAHA.112.660589. Epub 2013 Jan 3. PubMed PMID:23287786.

4: Petzold GC, Murthy VN. Role of astrocytes in neurovascular coupling. Neuron.2011 Sep 8;71(5):782-97. doi: 10.1016/j.neuron.2011.08.009. Review. PubMed PMID: 21903073.

5: Petzold GC, Hagiwara A, Murthy VN. Serotonergic modulation of odor input tothe mammalian olfactory bulb. Nat Neurosci. 2009 Jun;12(6):784-91. doi:10.1038/nn.2335. Epub 2009 May 10. PubMed PMID: 19430472.

6: Halle A, Hornung V, Petzold GC, Stewart CR, Monks BG, Reinheckel T, FitzgeraldKA, Latz E, Moore KJ, Golenbock DT. The NALP3 inflammasome is involved in theinnate immune response to amyloid-beta. Nat Immunol. 2008 Aug;9(8):857-65. doi:10.1038/ni.1636. Epub 2008 Jul 11. PubMed PMID: 18604209; PubMed Central PMCID:PMC3101478.

7: Petzold GC, Albeanu DF, Sato TF, Murthy VN. Coupling of neural activity toblood flow in olfactory glomeruli is mediated by astrocytic pathways. Neuron.2008 Jun 26;58(6):897-910. doi: 10.1016/j.neuron.2008.04.029. PubMed PMID:18579080; PubMed Central PMCID: PMC2922004.

8: Petzold GC, Haack S, von Bohlen Und Halbach O, Priller J, Lehmann TN,Heinemann U, Dirnagl U, Dreier JP. Nitric oxide modulates spreadingdepolarization threshold in the human and rodent cortex. Stroke. 2008Apr;39(4):1292-9. doi: 10.1161/STROKEAHA.107.500710. Epub 2008 Feb 28. PubMedPMID: 18309156.

9: Tyler WJ, Petzold GC, Pal SK, Murthy VN. Experience-dependent modification of primary sensory synapses in the mammalian olfactory bulb. J Neurosci. 2007 Aug29;27(35):9427-38. PubMed PMID: 17728456.

10: Petzold GC, Scheibe F, Braun JS, Freyer D, Priller J, Dirnagl U, Dreier JP. Nitric oxide modulates calcium entry through P/Q-type calcium channels andN-methyl-d-aspartate receptors in rat cortical neurons. Brain Res. 2005 Nov23;1063(1):9-14. Epub 2005 Nov 7. PubMed PMID: 16274675.

11: Pomper JK, Haack S, Petzold GC, Buchheim K, Gabriel S, Hoffmann U, Heinemann U. Repetitive spreading depression-like events result in cell damage in juvenile hippocampal slice cultures maintained in normoxia. J Neurophysiol. 2006Jan;95(1):355-68. Epub 2005 Sep 21. PubMed PMID: 16177179.

12: Dreier JP, Jurkat-Rott K, Petzold GC, Tomkins O, Klingebiel R, Kopp UA,Lehmann-Horn F, Friedman A, Dichgans M. Opening of the blood-brain barrierpreceding cortical edema in a severe attack of FHM type II. Neurology. 2005 Jun28;64(12):2145-7. PubMed PMID: 15985592.

13: Petzold GC, Windmüller O, Haack S, Major S, Buchheim K, Megow D, Gabriel S,Lehmann TN, Drenckhahn C, Peters O, Meierkord H, Heinemann U, Dirnagl U, DreierJP. Increased extracellular K+ concentration reduces the efficacy ofN-methyl-D-aspartate receptor antagonists to block spreading depression-likedepolarizations and spreading ischemia. Stroke. 2005 Jun;36(6):1270-7. Epub 2005 May 5. PubMed PMID: 15879337.

14: Jurkat-Rott K, Freilinger T, Dreier JP, Herzog J, Göbel H, Petzold GC,Montagna P, Gasser T, Lehmann-Horn F, Dichgans M. Variability of familialhemiplegic migraine with novel A1A2 Na+/K+-ATPase variants. Neurology. 2004 May25;62(10):1857-61. PubMed PMID: 15159495.

15: Petzold GC, Marcucci M, Butler MH, van Landeghem FK, Einhäupl KM, Solimena M,Valdueza JM, De Camilli P. Rhabdomyolysis and paraneoplastic stiff-man syndromewith amphiphysin autoimmunity. Ann Neurol. 2004 Feb;55(2):286-90. PubMed PMID:14755734.

16: Kleeberg J, Petzold GC, Major S, Dirnagl U, Dreier JP. ET-1 induces cortical spreading depression via activation of the ETA receptor/phospholipase C pathwayin vivo. Am J Physiol Heart Circ Physiol. 2004 Apr;286(4):H1339-46. Epub 2003 Dec4. PubMed PMID: 14656702.

17: Petzold GC, Einhäupl KM, Dirnagl U, Dreier JP. Ischemia triggered byspreading neuronal activation is induced by endothelin-1 and hemoglobin in thesubarachnoid space. Ann Neurol. 2003 Nov;54(5):591-8. PubMed PMID: 14595648.


Prof. Dr. Gabor Petzold
Prof. Dr. Gabor Petzold

DZNE

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