Klinik und Poliklinik für Neurologie


Magnetic resonance imaging (MRI) allows to visualize and quantitatively assess brain morphology. Recently, various new MRI methods have been developed that provide important new insights into the morphological alterations occurring in neurodegenerative diseases. Voxel-based morphometry (VBM) is helpful in comprehensively assessing anatomical differences of grey and white matter throughout the brain in an automated and unbiassed way. Voxel-based relaxometry (VBR) takes into account the additional information obtained from T2 relaxometry. Diffusion tensor imaging (DTI) is particularly useful in studying white matter fiber tracts.

We apply various MRI morphometric methods to patients with neurodegenerative disease, in particular multiple system atrophy (MSA), spinocerebellar atrophies (SCA) and myotonic dystrophy. Correlation of morphological parameters with clinical and performance measures provides a better understanding of the brain structural changes underlying neuronal dysfunction in these disorders. We are also interested in evaluating the potential of brain structural MRI as an outcome measure in clinical trials.

Key Publications

1: Hummel T, Fliessbach K, Abele M, Okulla T, Reden J, Reichmann H, Wüllner U, Haehner A. Olfactory FMRI in patients with Parkinson's disease. Front Integr Neurosci. 2010 Oct 28;4:125. PubMed PMID: 21120143; PubMed Central PMCID: PMC2991239.

2: Minnerop M, Lüders E, Specht K, Ruhlmann J, Schimke N, Thompson PM, Chou YY, Toga AW, Abele M, Wüllner U, Klockgether T. Callosal tissue loss in multiple system atrophy--a one-year follow-up study. Mov Disord. 2010 Nov 15;25(15):2613-20. PubMed PMID: 20623690; PubMed Central PMCID: PMC2989455.

3: Bucerius J, Manka C, Schmaljohann J, Mani V, Gündisch D, Rudd JH, Bippus R, Mottaghy FM, Wüllner U, Fayad ZA, Biersack HJ. Feasibility of [(18)F]-2-Fluoro-A85380-PET Imaging of Human Vascular Nicotinic Acetylcholine Receptors In Vivo. JACC Cardiovasc Imaging. 2012 May;5(5):528-36. PubMed PMID: 22595161.

4: Klinke I, Minnerop M, Schmitz-Hübsch T, Hendriks M, Klockgether T, Wüllner U, Helmstaedter C. Neuropsychological features of patients with spinocerebellar ataxia (SCA) types 1, 2, 3, and 6. Cerebellum. 2010 Sep;9(3):433-42. PubMed PMID: 20502998; PubMed Central PMCID: PMC2949561.

5: Minnerop M, Specht K, Ruhlmann J, Grothe C, Wüllner U, Klockgether T. In vivo voxel-based relaxometry in amyotrophic lateral sclerosis. J Neurol. 2009 Jan;256(1):28-34. Epub 2009 Feb 16. PubMed PMID: 19267168.

6: Nelles M, Block W, Träber F, Wüllner U, Schild HH, Urbach H. Combined 3T diffusion tensor tractography and 1H-MR spectroscopy in motor neuron disease. AJNR Am J Neuroradiol. 2008 Oct;29(9):1708-14. Epub 2008 Aug 13. PubMed PMID: 18701582.

7: Wüllner U, Gündisch D, Herzog H, Minnerop M, Joe A, Warnecke M, Jessen F, Schütz C, Reinhardt M, Eschner W, Klockgether T, Schmaljohann J. Smoking upregulates alpha4beta2* nicotinic acetylcholine receptors in the human brain. Neurosci Lett. 2008 Jan 3;430(1):34-7. Epub 2007 Oct 22. PubMed PMID: 17997038.

8: Patt M, Solbach C, Wüllner U, Blocher A, Stahlschmidt A, Gündisch D, Kovar KA, Machulla HJ. Synthetic approaches and bio-distribution studies of [11C]methyl-phenidate. J Pharm Pharm Sci. 2007;10(2):312s-320s. PubMed PMID: 17718934.

Prof. Dr. Thomas Klockgether
Prof. Dr. Thomas Klockgether


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