Klinik und Poliklinik für Neurologie

Publications

2014

Gauthier-Kemper A, Igaev M, Sündermann F, Janning D, Brühmann J, Moschner K, Reyher HJ, Junge W, Glebov K, Walter J, Bakota L, Brandt R: Interplay between phosphorylation and palmitoylation mediates plasma membrane targeting and sorting of GAP43. Mol. Biol. Cell, in press (2014)

Karaca I, Tamboli IY, Glebov K, Richter J, Fell LH, Grimm MO, Haupenthal VJ, Hartmann T, Gräler MH, van Echten-Deckert G, Walter J: Deficiency of Sphingosine-1-phosphate Lyase Impairs Lysosomal Metabolism of the Amyloid Precursor Protein. J Biol Chem. 289(24):16761-72. (2014)

van Echten-Deckert G, Hagen-Euteneuer N, Karaca I, Walter J: Sphingosine-1-phosphate: boon and bane for the brain. Cell Physiol Biochem. 34(1):148-57. (2014)

Kosicek M, Wunderlich P, Walter J, Hecimovic S: GGA1 overexpression attenuates amyloidogenic processing of the amyloid precursor protein in Niemann-Pick type C cells. Biochem Biophys Res Commun. 450(1):160-5. (2014)

Rezaei-Ghaleh N, Amininasab M, Giller K, Kumar S, Stündl A, Schneider A, Becker S, Walter J, Zweckstetter M: Turn plasticity distinguishes different modes of amyloid-ß aggregation. J Am Chem Soc. 136(13):4913-9. (2014)

Rijal Upadhaya A, Kosterin I, Kumar S, von Arnim CA, Yamaguchi H, Fändrich M, Walter J, Thal DR: Biochemical stages of amyloid-ß peptide aggregation and accumulation in the human brain and their association with symptomatic and pathologically preclinical Alzheimer's disease. Brain. 137(Pt 3):887-903. (2014)

Walter J: Erkenntnisse aus experimentellen Tiermodellen für Alzheimer. Was bleibt ohne Erinnerung? Demenz als medizinische und ethische Herausforderung. FORMAT Druckerei & Verlagsgesellschaft mbH (2014)

2013

Wunderlich P, Glebov K, Kemmerling N, Tien NT, Neumann H, Walter J: Sequential proteolytic processing of the triggering receptor expressed on myeloid cells-2 (TREM2) protein by ectodomain shedding and γ-secretase-dependent intramembranous cleavage. J Biol Chem. 288(46):33027-36. (2013)

Mertens J, Stüber K, Wunderlich P, Ladewig J, Kesavan JC, Vandenberghe R, Vandenbulcke M, van Damme P, Walter J, Brüstle O, Koch P: APP Processing in Human Pluripotent Stem Cell-Derived Neurons Is Resistant to NSAID-Based gamma-Secretase Modulation. Stem Cell Reports. 1(6):491-8. (2013)

Rijal Upadhaya A, Scheibe F, Kosterin I, Abramowski D, Gerth J, Kumar S, Liebau S, Yamaguchi H, Walter J, Staufenbiel M, Thal DR: The type of Aß-related neuronal degeneration differs between amyloid precursor protein (APP23) and amyloid ß-peptide (APP48) transgenic mice. Acta Neuropathol Commun. 1(1):77. (2013)

Walter J, Van Echten-Deckert, G: Cross-talk of membrane-lipids and Alzheimer-related proteins. Mol Neurodegener. 8:34. (2013)

Gonzalez M, Nampoothiri S, Kornblum C, Oteyza AC, Walter J, Konidari I, Hulme W, Speziani F, Schöls L, Züchner S, Schüle R: Mutations in phospholipase DDHD2 cause autosomal recessive hereditary spastic paraplegia (SPG54). Eur J Hum Genet. 21(11):1214-8. (2013)

Kumar S, Wirths O, Theil S, Gerth J, Bayer TA, Walter J: Early intraneuronal accumulation and increased aggregation of phosphorylated Abeta in a mouse model of Alzheimer's disease. Acta Neuropathol. 125(5):699-709. (2013)

Walter J: Fishing for function--distinct roles of Bace1 and Bace2 in Zebrafish development. J Neurochem. 127(4):435-7. (2013)

2012

Parr, C., R. Carzaniga, S.M. Gentleman, F. van Leuven, J. Walter, and M. Sastre: GSK3 inhibition promotes lysosomal biogenesis and the autophagic degradation of the amyloid-ß precursor protein. Mol Cell Biol. 32(21):4410-8. (2012)

Walter, J.: Sphingolipids in the regulation of Alzheimer disease associated proteins. Glycoscience, 20th Anniversary of the Mizutani foundation. 78-79 <2012)

Koch, P., I.Y. Tamboli, J. Mertens, P. Wunderlich, J. Ladewig, K. Stüber, H. Esselmann, J. Wiltfang, O. Brüstle, and J. Walter: Presenilin-1 L166P mutant human pluripotent stem cell-derived neurons exhibit partial loss of γ-secretase activity in endogenous amyloid-ß generation. Am. J. Pathol. 180(6):2404-16. (2012)

Upadhaya A.R., E. Capetillo-Zarate, I. Kosterin, D. Abramowski, S. Kumar, H. Yamaguchi, J. Walter, M. Fändrich, M. Staufenbiel, D.R. Thal: Dispersible amyloid ß-protein oligomers, protofibrils, and fibrils represent diffusible but not soluble aggregates: Their role in neurodegeneration in amyloid precursor protein (APP) transgenic mice. Neurobiol. Aging 33(11):2641-60. (2012)

Kumar, S., S. Singh, D. Hinze, M. Josten, H.-G. Sahl, M. Siepmann, and J. Walter: Phosphorylation of the amyloid- peptide at serine 8 attenuates its clearance via insulin degrading and angiotensin converting enzymes. J. Biol. Chem. 287(11) (2012)

Liu, S.,Y. Liu, W. Hao, L. Wolf, A.J. Kiliaan, B. Penke, C.E. Rübe, J, Walter, M.T. Heneka, T. Hartmann, M.D. Menger, and K. Fassbender: Toll-like receptor 2 is a primary receptor for Alzheimer's amyloid peptide to trigger neuroinflammatory activation. J. Immunol. 1;188(3):1098-107. (2012)

Van Echten-Deckert, G. and J. Walter: Sphingolipids: Critical players in Alzheimer's disease. Prog. Lipid Res. 51(4):378-93. (2012)

Glebov, K. and J. Walter: Statins in unconventional secretion of insulin-degrading enzyme and degradation of the amyloid-[beta] peptide. Neurodeg. Dis. 10(1-4):309-12. (2012)

Klionsky, D.J., F.C. Abdalla,…, J. Walter,…, B. Zuckerbraun: Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy April 445 - 544 (2012)

J. Walter: gamma-Secretase, Apolipoprotein E and Cellular Cholesterol Metabolism. Curr Alzheimer Re. 9(2):189-99 (2011)

2011

Kummer, M.P., M. Hermes, A. Delekarte, T. Hammerschmidt, S. Kumar, D. Terwel, J. Walter, H.-C. Pape, S. König, S. Roeber, F. Jessen, T. Klockgether, M. Korte, and M.T. Heneka: Nitration of tyrosine 10 critically enhances amyloid beta aggregation and plaque formation. Neuron 71(5):833-44. (2011)

Kilger, E., A. Buehler, H. Woelfing, S. Kumar, S.A. Kaeser, A. Nagarathinam, J. Walter, M. Jucker, and J. Coomaraswamy: BRI2 regulates ß-amyloid degradation by increasing levels of secreted insulin degrading enzyme (IDE). J. Biol. Chem. 286(26):22711-5. (2011)

Glebov, K., S. Schütze, and J. Walter: Functional relevance of a novel SlyX motif in non-conventional secretion of insulin-degrading enzyme. J.Biol. Chem. 286(26):22711-5. (2011)

Kumar, S. , N. Rezaei-Ghaleh,D. Terwel, D.R. Thal, M. Richard, M. Hoch, J.M. Mc Donald, U. Wüllner, K. Glebov, M.T. Heneka, D.M. Walsh, M. Zweckstetter, and J. Walter: Extracellular phosphorylation of the amyloid ß-peptide promotes formation of toxic aggregates during the pathogenesis of Alzheimer's disease. EMBO 30(11):2255-65. (2011)

Tamboli, I.Y., T. Nguyen, and J. Walter: Sphingolipid storage impairs autophagic clearance of Alzheimer-associated proteins. Autophagy. (6):645-6. (2011)

Kumar, S. and J. Walter: Phosphorylation of amyloid beta-peptides: A trigger for formation of toxic aggregates in Alzheimer's disease. Aging 3(8):803-12. (2011)

Tamboli, I.Y., H. Hampel, T. Nguyen, K. Tolksdorf, B. Breiden, P.M. Mathews, P. Saftig, K. Sandhoff, and J. Walter: Sphingolipid storage affects autophagic metabolism of the amyloid precursor protein and promotes Aß generation. J.Neurosci. 31(5):1837-49. (2011)

2010

Wirths, O., C. Erck, H. Martens, A. Harmeier, C. Geumann, S. Jawhar, S. Kumar, G. Multhaup, J. Walter, M. Ingelsson, M. Degerman-Gunnarsson, H. Kalimo, I. Huitinga, L. Lannfelt, and T.A Bayer: Identification of low molecular weight pyroglutamate abeta oligomers in Alzheimer disease: a novel tool for therapy and diagnosis. J.Biol. Chem. 285(53):41517-24. (2010)

Siepmann, M., S. Kumar, G. Mayer, and J. Walter: Casein kinase 2 dependent phosphorylation of neprilysin regulates receptor tyrosine kinase signaling to Akt. PLoS ONE 5(10). pii: e13134. (2010)

Tamboli IY, E. Barth, L. Christian, M. Siepmann, S. Singh, S. Kumar, K. Tolksdorf, M.T. Heneka, D. Lütjohann, P. Wunderlich, and J. Walter:Statins promote the degradation of extracellular amyloid-peptide by microglia via stimulation of exosome-associated IDE secretion. J.Biol. Chem. 285(48):37405-14. (2010)

Stirnberg, M., E. Maurer, A. Horstmeyer, S. Kolp, S. Frank, T. Bald, K. Arenz, A. Janzer, K. Prager, P. Wunderlich, J. Walter, and M. Gütschow: The proteolytic processing of the serine protease matriptase-2: Identification of the cleavage sites required for its autocatalytic release from the cell surface. Biochem. J. 430(1):87-95. (2010)

Venkataramani, V., C. Rossner, L. Iffland, S. Schweyer, I. Tamboli, J. Walter, O. Wirths, T.A. Bayer: The histone deacetylase inhibitor valproic acid inhibits cancer cell proliferation via down-regulation of the Alzheimer amyloid precursor protein. J. Biol. Chem. 285(14):10678-89. (2010)

Heneka, M.T., F. Nadrigny , T. Regen , A. Martinez-Hernandez , L. Dumitrescu-Ozimek , D. Terwel, D. Jardanhazi-Kurutz , J. Walter , F. Kirchhoff , U. Hanisch , M. Kummer: Locus ceruleus controls Alzheimer disease pathology by modulating microglial functions through norepinephrine. Proc. Natl. Acad. Sci. USA 107(13):6058-63 (2010)

2009

Clement, A.B, M. Gamerdinger, I.Y. Tamboli, D. Lütjohann, J. Walter, I. Greeve, G. Gimpl, C. Behl: Adaptation of neuronal cells to chronic oxidative stress is associated with altered cholesterol and sphingolipid homeostasis and lysosomal function. J. Neurochem. 111, 669-682 (2009).

Mueller T., P. Breuer, I. Schmitt, J. Walter, B.O. Evert, U. Wüllner: CK2-dependent phosphorylation determines cellular localization and stability of ataxin-3. Hum. Mol. Genet. 18, 3334-3343 (2009).

Waschbüsch D., S. Born, V. Niediek, N. Kirchgeßner, I.Y. Tamboli, J. Walter, R. Merkel, B. Hoffmann: Presenilin 1 affects focal adhesion site formation and cell force generation via c-Src transcriptional and posttranslational regulation. J. Biol. Chem. 284, 10138-10149 (2009).

2008

Tamboli I.Y., K. Prager, D.R. Thal, K.M. Thelen, I. Dewachter, C.U. Pietrzik, P. St George-Hyslop, S.S. Sisodia, B. De Strooper, M.T. Heneka, M.A. Filippov, U. Müller, F. van Leuven, D. Lütjohann, J. Walter: Loss of gamma-secretase function impairs endocytosis of lipoprotein particles and membrane cholesterol homeostasis. J Neurosci. 28(46), 12097-12106 (2008).

Utter S., I.Y. Tamboli, J. Walter, A.R. Upadhaya, G. Birkenmeier, C.U. Pietrzik, E. Ghebremedhin, D.R. Thal: Cerebral small vessel disease-induced apolipoprotein E leakage is associated with Alzheimer disease and the accumulation of amyloid beta-protein in perivascular astrocytes. J Neuropathol Exp Neurol. 67(9), 842-856 (2008).

Sastre M., J. Walter, S.M. Gentleman: Interactions between APP secretases and inflammatory mediators. J Neuroinflammation 5:25 (2008).

2007

Prager K., L. Wang-Eckhardt, R. Fluhrer, R. Killick, E. Barth, H. Hampel, C. Haass, J. Walter: A Structural Switch of Presenilin 1 by Glycogen Synthase Kinase 3β-mediated Phosphorylation Regulates the Interaction with β-Catenin and Its Nuclear Signaling. J. Biol. Chem. 282, 14083-14093 (2007).

Wahle, T. and Walter, J.: Subcellular trafficking of BACE1: Molecular mechanisms in the control of ß-amyloid generation. Cogn. Sci. 3, 1 - 20 (2007).

Sastre, M. and Walter, J.: Secretases and inflammation. Recent advances in the biology of secretases, key proteases in Alzheimer disease (2007).

2006

Wahle T., D.R. Thal, M. Sastre, A. Rentmeister, N. Bogdanovic, M. Famulok, M.T. Heneka, and J. Walter: GGA1 is expressed in the human brain and affects the generation of amyloid β-peptide. J. Neurosci. 26(49), 12838-12846 (2006).

Rentmeister A., A. Bill, T. Wahle, J. Walter, and M. Famulok: RNA adapters selectively modulate protein recruitment to the cytoplasmic domain of β-secretase BACE1 in vitro. RNA 12, 1650-1660 (2006).

Kern A., B. Roempp, K. Prager, J. Walter, C. Behl: Down-regulation of endogenous amyloid precursor protein processing due to cellular aging. J Biol Chem. 281, 2405-2413 (2006).

Sastre M., S. Rossner, N. Bogdanovic, E. Rosen, I. Dewachter, D.R. Thal, B.O. Evert, J. Walter, T. Klockgether, F. van Leuven, and M.T. Heneka: NSAIDs repress BACE1 gene promoter activity by activation of the peroxisome proliferators-activated receptor-γ (PPARγ). Proc. Natl. Acad. Sci. USA 103, 443-448 (2006).

Walter J.: Control of amyloid-β-peptide generation by subcellular trafficking of the β-amyloid precursor protein and β-secretase. Neurodeg. Dis. 3, 247-254 (2006).

Tamboli I.Y., K. Prager, E. Barth, M. Heneka, K. Sandhoff, J. Walter: Modulation of proteolytic processing by glycosphingolipids generates amyloid β-peptide In Sphingolipid Biology (eds. Y. Hirabayashi, Y. Igarashi, A.H. Merril, Jr.) Springer Verlag, Tokyo, Berlin, Heidelberg, New York, 319-338 (2006).

2005

Heneka M.T., M. Sastre, L. Dumitrescu-Ozimek, I. Dewachter, J. Walter, T. Klockgether, F. Van Leuven: Focal glial activation coincides with increased BACE1 activation and precedes amyloid plaque deposition in APP[V717I] transgenic mice. J. Neuroinflammation 2:22 (2005).

Tamboli I.Y., K. Prager, E. Barth, M. Heneka, K. Sandhoff, J. Walter: Inhibition of glycosphingolipid biosynthesis reduces secretion of the beta-amyloid precursor protein and amyloid beta-peptide. J. Biol. Chem. 280, 28110-28117 (2005).

Wahle T., K. Prager, N. Raffler, C. Haass, M. Famulok, J. Walter: GGA proteins regulate retrograde transport of BACE1 from endosomes to the trans-Golgi network. Mol. Cell. Neurosci. 29, 453-461 (2005).

2004

Fluhrer R., A. Friedlein, C. Haass, and J. Walter: Phosphorylation of presenilin 1 at the caspase recognition site regulates ist proteolytic processing and the progression of apoptosis. J. Biol. Chem. 279, 1585-1593 (2004).

Walter J., C. Haass: Zellbiologische Grundlagen der Alzheimer-Demenz. In Gerontopsychiatrie (eds. W. Bergener, H. Hampel, Zaudig) Wissenschaftliche Verlagsgesellschaft mbH, Stuttgart, Germany, 46-58 (2004).

2003

Fluhrer R., G. Multhaup, A.Schlicksupp, M. Okochi, M. Takeda, S. Lammich, M. Willem, G.Westmeyer, J. Walter*, and C. Haass*: Identification of a β-secretase activity truncates amyloid β-peptide after its presenilin dependent generation. J. Biol. Chem. 278, 5531-5538 (2003). *equal contributions

Walter, J.: Molekularbiologie der Alzheimer Krankheit. In BIOforum 6/2003, GIT Verlag, Darmstadt, Germany, in press (2003).

2002

Lammich S., M. Okochi, M. Takeda, C. Kaether, A. Capell, A.K. Zimmer, D. Edbauer, J. Walter, H. Steiner, and C. Haass: Presenilin dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide. J. Biol. Chem. 277, 4475-4479 (2002).

Fluhrer R., A. Capell, G. Westmeyer, M. Willem, B. Hartung, M.M. Condron, D.B. Teplow, C. Haass, and J. Walter: A non-amyloidogenic function of BACE-2 in the secretory pathway. J. Neurochem. 81, 1011-1020 (2002).

Capell A., L. Meyn, R. Fluhrer, D.B. Teplow, J. Walter, and C. Haass: Apical sorting of beta-secretase limits amyloid beta-peptide production. J. Biol. Chem. 277, 5637-5643 (2002).

Walter, J. and C. Haass: Molekulare Zellbiologie der Alzheimer-Demenz. In Lehrbuch der Geronto-psychiatrie und –psychotherapie (ed. H. Förstl) Georg Thieme Verlag, Stuttgart, Germany, 37-45 (2002).

Walter, J. and C. Haass: Secretases as targets for beta-amyloid lowering drugs Drug Dev. Res. 56, 201-210 (2002).

2001

Walter J., R. Fluhrer, B. Hartung, M. Willem, C. Kaether, A. Capell, S. Lammich, G. Multhaup, and C. Haass: Phosphorylation regulates intracellular trafficking of β-secretase (BACE). J. Biol. Chem. , 276, 14634-14641 (2001).

Walter, J., C. Kaether, H. Steiner, and C. Haass: Molecular Biology of Alzheimer’s disease: Uncovering the secrets of secretases. Curr. Opin. Neurobiol. 11, 585-590 (2001).

2000

Okochi M., S. Eimer, R. Baumeister, H. Romig, J. Walter, A. Capell, H. Steiner, and C. Haass: Loss of function of a mutant presenilin homoloque in Ceanorhabditis elegans is associated with its aberrant endoproteolysis. J. Biol. Chem. 275, 40925-40932 (2000).

Mathews P.M., A.M. Cataldo, B.H. Kao, A.G. Rudnicki, X. Qui, J.L. Yang, Y. Jiang, C. Hulette, K. Dole, C.F. Lippa, T.D. Bird, D. Nochlin, J. Walter, C. Haass, L. Levesque, P.E. Fraser, A. Andreadis, and R. Nixon: Brain expression of presenilins in sporadic and early-onset familial Alzheimer’s disease. Mol. Med. , 6, 878-91 (2000).

Capell A., H. Steiner, M. Willem, H. Kaiser, C. Meyer, J. Walter, S. Lammich, G. Multhaup, and C. Haass: Maturation and propeptide cleavage of β-secretase. J. Biol. Chem. 275, 30849-30546 (2000).

Walter J., A. Schindzielorz, B. Hartung, and C. Haass: Cell surface phosphorylation of the β-amyloid precursor protein by ectoprotein kinases CK1 and CK2. J. Biol. Chem. 275, 23523-23529 (2000).

Kulic L., J. Walter, G. Multhaup, D.B. Teplow, H. Romig, A. Capell, H. Steiner, R. Baumeister, and C. Haass: Separation of presenilin function in amyloid β-peptide generation and endoproteolysis of Notch. Proc. Natl. Acad. Sci. USA 97, 5913-5918 (2000).

Meijer L., A.-M. W.H. Thunnissen, A.W. White, M. Garnier, M. Nikolic, L.-H. Tsai, J. Walter, K. Cleverley, P.C. Salinas, Y.-Z. Wu, J. Biernat, E.-M. Mandelkow, S.-H. Kim, and G. Pettit: Inhibition of cyclin-dependent kinases 1, 2 & 5, GSK-3β, and casein kinase 1 by hymenialdisine, a marine sponge constituent. Crystal structure of a CDK2/hymenialdisine complex. Chem. Biol. , 1, 51-63 (2000).

Okochi M., J. Walter, A. Koyama, S. Nakajo, M. Baba, T. Iwatsubo, L. Meijer, G.Pettit, P. Kahle, and C. Haass: Constitutive phosphorylation of the Parkinson’s diesease associated alpha-synuclein. J. Biol. Chem. , 275, 390-397 (2000).

Walter, J.: Phosphorylation of Presenilin Proteins. Methods Mol Med. 32:317-31. (2000).

Walter, J., and C. Haass: Posttranslational modifications of amyloid precursor protein: ectodomain phosphorylation and sulfation. Methods Mol Med. 32:149-68. (2000).

1999

Leimer U., K. Lun, H. Romig, J. Walter, J. Grünberg, M. Brand, and C. Haass: Zebrafish (Danio rerio) presenilin promotes aberrant amyloid β-peptide production and requires a critical aspartate residue for ist function in amyloidogenesis. Biochemistry 38, 13602-13609 (1999).

Walter J., A. Schindzielorz, J. Grünberg, and C. Haass: Phosphorylation of Presenilin-2 inhibits its caspase mediated cleavage and retards the progression of apoptosis. Proc. Natl. Acad. Sci. USA 96, 1391-1396 (1999).

Grünberg, J., J. Walter, and C. Haass: The 18-20 kDa C-terminal fragment of presenilin-1 is the major in vivo substrate for proteases of the caspase family. Alzheimer’s Disease and Related Dissorders (eds. K. Iqbal, B. Windblad) Wiley & sons Ltd., Chichester, West Sussex, England, 213-220 (1999).

Schindzielorz, A., J. Grünberg, C. Haass, and J. Walter: Characterization of Protein Kinases Phosphorylating the β-Amyloid Precursor Protein Within its Ectodomain and Identification of In Vivo Phosphorylation Sites. Alzheimer’s Disease and Related Dissorders (eds. K. Iqbal, B. Windblad) Wiley & sons Ltd., Chichester, West Sussex, England, 231-239 (1999).

Röhrig S., M. Brockhaus, H. Steiner, A. Capell, J. Grünberg, J. Walter, U. Leimer, H. Loetscher, N. Wittenburg, H. Jacobsen, R. Baumeister, and C. Haass: Role of Presenilin Processing and Caspases for Amyloid β-Peptide Generation and Notch-signalling. Alzheimer’s Disease and Related Dissorders (eds. K. Iqbal, B. Windblad) Wiley & sons Ltd., Chichester, West Sussex, England, 353-362 (1999).

1998

Grünberg J.*, J. Walter*, C. Eckman, A. Capell, A. Schindzielorz, S. Younkin, N. Mehta, J. Hardy, and C. Haass: Truncated presenilin-2 derived from differentially spliced mRNAs does not affect the ratio of amyloid β-peptide 1-42/1-40. NeuroReport 9, 3293-3299 (1998). *both authors contributed equally to this work.

Walter J., J. Grünberg, A. Schindzielorz, and C. Haass: Proteolytic fragments of the Alzheimer's disease associated presenilins-1 and -2 are phosphorylated in vivo by distinct cellular mechanisms. Biochemistry 37, 5961-5967 (1998).

Oyama F., N. Sawamura, K. Kobayashi, M. Morishima-Kawashima, T. Kuramochi, M. Ito, T. Tomita, K. Maruyama, T.C. Saido, T. Iwatsubo, A. Capell, J. Walter, J. Grünberg, Y. Ueyama, C. Haass, and Y. Ihara: Mutant Presenilin-2 Transgenic Mouse: Effect on an age-dependent increase of amyloid β-protein 42 in the brain. J. Neurochem. 71, 313-322 (1998).

Grünberg J., J. Walter, H. Loetscher, U. Deuschle, H. Jacobsen, and C. Haass: Alzheimer’s Disease Associated Presenilin-1 Holoprotein and Its 18-20 kDa C-terminal Fragment Are Death Substrates for Proteases of the Caspase Family. Biochemisty 37, 2263-2270 (1998).

Haass, C., J. Grünberg, A. Capell, C. Wild-Bode, U. Leimer, J. Walter, T. Yamazaki, I. Ihara, I. Zweckbronner, C. Jakubek, and R. Baumeister: Proteolytic processing of Alzheimer’s disease associated proteins. J. Neural Transm . 53, 159-167 (1998).

Walter, J., and C. Haass: The Phosphorylation of Presenilin Proteins. In Molecular Biology of Alzheimer’s Disease (ed. C. Haass) Harwood Academic Publishers, Amsterdam, The Netherlands, 277-287 (1998).

Haass, C., J. Walter, A. Capell, C. Wild-Bode, J. Grünberg, T. Yamazaki, I. Ihara, I. Zweckbronner, C. Jakubek, and R. Baumeister: The Cellular Biology of Presenilin Proteins and A Novel Mechanism of Amyloid β-Peptide Generation. In Alzheimer’s Disease (eds. S. Younkin, R. Tanzi, and E. Christen) Springer Verlag, Heidelberg, Germany, 71-78 (1998).

1997

Walter J., J. Grünberg, A. Capell, B. Pesold, A. Schindzielorz, K. Mendla, P.H. St George-Hyslop, G. Multhaup, D.J. Selkoe and C. Haass: Proteolytic Processing of the Alzheimer’s Disease Associated Presenilin-1 Generates an in vivo Substrate for Protein Kinase C. Proc. Natl. Acad. Sci. USA 94, 5349-5354 (1997).

Capell A., R. Saffrich, J.-C. Olivo, L. Meyn, J. Walter, J. Grünberg, C. Dotti, and C. Haass: Cellular Expression and Proteolytic Processing of Presenilin Proteins is Developmentally Regulated During Neuronal Differentiation, J. Neurochem. 69, 2432-2440 (1997).

Tomita T., K. Maruyama, T.C. Saido, H. Kume, K. Shinozaki, S., Tokuhiro, A. Capell, J. Walter, J. Grünberg, C. Haass, T. Iwatsubo and K. Obata: The Presenilin 2 Mutation (N141I) Linked to Familial Alzheimer’s Disease (Volga German Families) Increases the Secretion of Amyloid β-Protein at Aβ 42(43). Proc. Natl. Acad. Sci. USA 94, 2025-2030 (1997).

Walter J., A. Capell, A.Y. Hung, H. Langen, M. Schnölzer, G. Thinakaran, S.S. Sisodia, D.J. Selkoe and C. Haass: Ectodomain Phosphorylation of β-Amyloid Precursor Protein at Two Distinct Cellular Locations. J. Biol. Chem. 272, 1896-1903 (1997).

Grünberg, J., A. Capell, U. Leimer, B. Steiner, H. Steiner, J. Walter, and C. Haass: Proteolytic Processing of Presenilin Proteins: Degradation or Biological Activation ? Alzheimer Res . 3, 253-259 (1997).

1996

Walter J., A. Capell, J. Grünberg, B. Pesold, A. Schindzielorz, R. Prior, M. Podlisny, P. Fraser, P.H. St George-Hyslop, D.J. Selkoe and C. Haass: The Alzheimer's Disease Associated Presenilins are Differentially Phosphorylated Proteins Localized in the Endoplasmic Reticulum. Mol. Med. 2, 673-691 (1996).

Walter J., M. Schnölzer, W. Pyerin, V. Kinzel and D. Kubler: Induced Release of Ecto-Protein Kinase Yields CK-1 and CK-2 in Tandem. J. Biol. Chem. 271, 111-119 (1996).

1994

Walter J., V. Kinzel, D. Kubler: Evidence for CKI and CKII at the cell surface. Cell. Mol. Biol. Res. 40, 473-480 (1994).